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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2003-9-23
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pubmed:abstractText |
We present 3 cases of large B-cell lymphoma (LBCL) with a granular cytoplasmic staining for anaplastic lymphoma kinase (ALK). All of the cases showed striking similarities in morphology and immunohistochemical profile characterized by a massive monomorphic proliferation of CD20-/CD138+ plasmablast-like cells. In one of the cases, initially diagnosed as a null-type anaplastic large cell lymphoma (ALCL), the B-cell phenotype became evident only at recurrence. Fluorescent in situ hybridization (FISH) and molecular studies led to the detection of a CLTC-ALK rearrangement in all 3 cases, without any evidence of full-length ALK receptor expression. The associated t(2;17)(p23;q23) was demonstrated in the karyotype of 2 cases. Although a similar CLTC-ALK aberration was previously identified in ALK-positive T-/null cell ALCL and inflammatory myofibroblastic tumor, its association with ALK-positive LBCL seems to be specific and intriguing.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0006-4971
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pubmed:author |
pubmed-author:BaensMathijsM,
pubmed-author:De PaepePascaleP,
pubmed-author:De Wolf-PeetersChrisC,
pubmed-author:DohseCC,
pubmed-author:LaureysGenevièveG,
pubmed-author:MarynenPeterP,
pubmed-author:PoppeBruceB,
pubmed-author:PraetMarleenM,
pubmed-author:SimonsAnnetA,
pubmed-author:SpelemanFrankF,
pubmed-author:StulMichelM,
pubmed-author:VandenberghePeterP,
pubmed-author:VerhasseltBrunoB,
pubmed-author:WlodarskaIwonaI,
pubmed-author:van KriekenHanH
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2638-41
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:12750159-Adolescent,
pubmed-meshheading:12750159-Adult,
pubmed-meshheading:12750159-Amino Acid Sequence,
pubmed-meshheading:12750159-Base Sequence,
pubmed-meshheading:12750159-Child,
pubmed-meshheading:12750159-Chromosomes, Human, Pair 17,
pubmed-meshheading:12750159-Chromosomes, Human, Pair 2,
pubmed-meshheading:12750159-Clathrin,
pubmed-meshheading:12750159-Female,
pubmed-meshheading:12750159-Genotype,
pubmed-meshheading:12750159-Humans,
pubmed-meshheading:12750159-Lymphoma, B-Cell,
pubmed-meshheading:12750159-Male,
pubmed-meshheading:12750159-Molecular Sequence Data,
pubmed-meshheading:12750159-Oncogene Proteins, Fusion,
pubmed-meshheading:12750159-Phenotype,
pubmed-meshheading:12750159-Protein-Tyrosine Kinases,
pubmed-meshheading:12750159-Receptor Protein-Tyrosine Kinases
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pubmed:year |
2003
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|
pubmed:articleTitle |
ALK activation by the CLTC-ALK fusion is a recurrent event in large B-cell lymphoma.
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pubmed:affiliation |
Department of Pathology, Center of Medical Genetics and Pediatric Oncology, Ghent University Hospital, Belgium.
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pubmed:publicationType |
Journal Article,
Case Reports
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