rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
|
pubmed:dateCreated |
2003-5-16
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pubmed:abstractText |
A series of 1-aryloxy-3-piperidinylpropan-2-ols possessing potent dual 5-HT(1A) receptor antagonism and serotonin reuptake inhibition was discovered. 1-(1H-Indol-4-yloxy)-3-(4-benzo[b]thiophen-2-ylpiperidinyl)propan-2-ols exhibited selective and high affinity at the 5-HT(1A) receptor and serotonin reuptake inhibition at nanomolar concentrations for dual activities.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:AhmadLaura JLJ,
pubmed-author:HonigschmidtNicholas ANA,
pubmed-author:KochDaniel JDJ,
pubmed-author:KohnTodd JTJ,
pubmed-author:NelsonDavid LDL,
pubmed-author:RoccoVincent PVP,
pubmed-author:ShawJaniceJ,
pubmed-author:SpinazzePatrick GPG,
pubmed-author:TakeuchiKumikoK,
pubmed-author:ThrelkeldPenny GPG,
pubmed-author:WainscottD BradleyDB,
pubmed-author:WongDavid TDT
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pubmed:issnType |
Print
|
pubmed:day |
2
|
pubmed:volume |
13
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1903-5
|
pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12749894-Antidepressive Agents, Second-Generation,
pubmed-meshheading:12749894-Guanosine 5'-O-(3-Thiotriphosphate),
pubmed-meshheading:12749894-Indoles,
pubmed-meshheading:12749894-Paroxetine,
pubmed-meshheading:12749894-Propanols,
pubmed-meshheading:12749894-Receptor, Serotonin, 5-HT1A,
pubmed-meshheading:12749894-Serotonin 5-HT1 Receptor Antagonists,
pubmed-meshheading:12749894-Serotonin Uptake Inhibitors,
pubmed-meshheading:12749894-Structure-Activity Relationship
|
pubmed:year |
2003
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pubmed:articleTitle |
Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 1.
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pubmed:affiliation |
Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA. ktak@lilly.com
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pubmed:publicationType |
Journal Article
|