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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-5-15
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pubmed:abstractText |
The mammalian target of rapamycin, mTOR, is a serine/threonine kinase that controls cell growth and proliferation via the translation regulators eukaryotic initiation factor 4E (eIF4E) binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1). We recently identified a TOR signaling (TOS) motif in the N terminus of S6K1 and the C terminus of 4E-BP1 and demonstrated that in S6K1, the TOS motif is necessary to facilitate mTOR signaling to phosphorylate and activate S6K1. However, it is unclear how the TOS motif in S6K1 and 4E-BP1 mediates mTOR signaling.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/EIF4EBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Eukaryotic Initiation Factor-4E,
http://linkedlifedata.com/resource/pubmed/chemical/MTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RPS6KA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RPTOR protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ribosomal Protein S6 Kinases, 90-kDa,
http://linkedlifedata.com/resource/pubmed/chemical/TOR Serine-Threonine Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
13
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
797-806
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12747827-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:12747827-Amino Acid Motifs,
pubmed-meshheading:12747827-Amino Acid Substitution,
pubmed-meshheading:12747827-Binding Sites,
pubmed-meshheading:12747827-Carrier Proteins,
pubmed-meshheading:12747827-Cell Line,
pubmed-meshheading:12747827-Cell Line, Tumor,
pubmed-meshheading:12747827-Cell Size,
pubmed-meshheading:12747827-Eukaryotic Initiation Factor-4E,
pubmed-meshheading:12747827-Humans,
pubmed-meshheading:12747827-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12747827-Phosphoproteins,
pubmed-meshheading:12747827-Phosphorylation,
pubmed-meshheading:12747827-Protein Kinases,
pubmed-meshheading:12747827-Proteins,
pubmed-meshheading:12747827-Recombinant Fusion Proteins,
pubmed-meshheading:12747827-Ribosomal Protein S6 Kinases, 90-kDa,
pubmed-meshheading:12747827-Signal Transduction,
pubmed-meshheading:12747827-TOR Serine-Threonine Kinases,
pubmed-meshheading:12747827-Transfection
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pubmed:year |
2003
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pubmed:articleTitle |
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function.
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pubmed:affiliation |
The Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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