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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-5-14
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pubmed:abstractText |
The genes involved in the serotonin system are major candidates in association studies on affective disorders and responses to antidepressants. We studied a functional polymorphism of the serotonin transporter (5-HTT) gene (a 44 bp insertion/deletion in the 5-HTT-linked polymorphic region (5-HTTLPR)) and lifetime history of antidepressant-induced mania (AIM) in a population of 305 patients with bipolar affective disorder. AIM was defined using a broad definition and a restrictive definition. No association was found between the "s" allele of the 5-HTTLPR and AIM for either definition. However, we found an association between the 5-HTTLPR and lifetime history of rapid cycling in a subsample of patients (for allele and genotype distributions: exact probability, p=0.0009 and chi(2)=9.4; df=1; p=0.002, respectively). These results may help to explain the conflicting association results obtained with the 5-HTT gene polymorphism, in particular with AIM. Indeed, the precise phenotype associated with the 5-HTT gene is unclear. The association between the "s" allele and rapid cycling may provide further evidence for an association between the 5-HTTLPR "s" allele and a pattern of affective instability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1470-269X
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pubmed:author |
pubmed-author:AubryJ-MJM,
pubmed-author:BaudPP,
pubmed-author:BellivierFF,
pubmed-author:BoucherieMM,
pubmed-author:BuresiCC,
pubmed-author:FerreroFF,
pubmed-author:FournierGG,
pubmed-author:HenryCC,
pubmed-author:LaplancheJ-LJL,
pubmed-author:LeboyerMM,
pubmed-author:MalafosseAA,
pubmed-author:RoussevaAA,
pubmed-author:van den BulkeDD
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pubmed:issnType |
Print
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
101-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12746735-Adult,
pubmed-meshheading:12746735-Antidepressive Agents,
pubmed-meshheading:12746735-Bipolar Disorder,
pubmed-meshheading:12746735-Carrier Proteins,
pubmed-meshheading:12746735-DNA,
pubmed-meshheading:12746735-DNA Primers,
pubmed-meshheading:12746735-Female,
pubmed-meshheading:12746735-Humans,
pubmed-meshheading:12746735-Male,
pubmed-meshheading:12746735-Membrane Glycoproteins,
pubmed-meshheading:12746735-Membrane Transport Proteins,
pubmed-meshheading:12746735-Middle Aged,
pubmed-meshheading:12746735-Mutation,
pubmed-meshheading:12746735-Nerve Tissue Proteins,
pubmed-meshheading:12746735-Polymorphism, Genetic,
pubmed-meshheading:12746735-Psychiatric Status Rating Scales,
pubmed-meshheading:12746735-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12746735-Serotonin Plasma Membrane Transport Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Antidepressant-induced mania, rapid cycling and the serotonin transporter gene polymorphism.
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pubmed:affiliation |
Service de Psychiatrie, Hôpital Henri Mondor et Albert Chenevier, Assistance Publique-Hôpitaux de Paris, 51 Avenue du Marechal de Lattre de Tassigny, 94010 Créteil, France.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, Non-U.S. Gov't
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