|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0017243,
umls-concept:C0030685,
umls-concept:C0141745,
umls-concept:C0331858,
umls-concept:C0391871,
umls-concept:C0449774,
umls-concept:C0678594,
umls-concept:C0680255,
umls-concept:C0871161,
umls-concept:C1283071,
umls-concept:C1704640,
umls-concept:C1706515,
umls-concept:C1707520,
umls-concept:C1963578
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|
pubmed:issue |
2
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|
pubmed:dateCreated |
2003-5-14
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|
pubmed:abstractText |
The drug delivery behavior of scleroglucan hydrogels was correlated with the structural features found by means of steady-state fluorescence studies. Theophylline at 0.4% in weight was used as the model drug and its release was measured using a Franz cell device. The results were fitted with a semi-empirical power law equation, finding significant differences between the 0.5% and higher than 0.8% scleroglucan concentrations (w/w). Four molecular fluorescent probes were used to test microenvironmental properties of the gel cavities, which will play a key role on the release of the pharmaceutical drugs. The results found by the fluorescence analysis are in good agreement with the ones obtained by release kinetics.
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pubmed:language |
eng
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pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1071-7544
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
79-85
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pubmed:meshHeading |
|
|
pubmed:articleTitle |
Correlation between gel structural properties and drug release pattern in scleroglucan matrices.
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|
pubmed:affiliation |
Laboratorio de Química de Sistemas Heterogéneos, Facultad de Ingeniería, Universidad de Buenos Aires, Buenos Aires, Argentina.
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pubmed:publicationType |
Journal Article
|
