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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0017262,
umls-concept:C0019721,
umls-concept:C0023418,
umls-concept:C0041904,
umls-concept:C0127400,
umls-concept:C0162493,
umls-concept:C0185117,
umls-concept:C0456387,
umls-concept:C0683598,
umls-concept:C2709199,
umls-concept:C2911684
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pubmed:issue |
5
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pubmed:dateCreated |
2003-5-14
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pubmed:abstractText |
Drug-resistant leukemia cells may exhibit cross-resistance towards immunological effector mechanisms by alterations of apoptosis pathways. This is particularly relevant in allogeneic bone marrow transplantation for leukemia, where the graft-versus-leukemia effect acts on cells pretreated with cytostatic drugs. Here, we clarify the mechanism underlying cross-resistance of drug-resistant variants of the T-leukemia cell line CEM towards natural killer cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Doxorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/GZMB protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Granzymes,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Poly(ADP-ribose) Polymerases,
http://linkedlifedata.com/resource/pubmed/chemical/Serine Endopeptidases
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1592-8721
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
509-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12745270-Antigens, CD95,
pubmed-meshheading:12745270-Antineoplastic Agents,
pubmed-meshheading:12745270-Caspases,
pubmed-meshheading:12745270-Cell Nucleus,
pubmed-meshheading:12745270-Cells, Cultured,
pubmed-meshheading:12745270-Cytotoxicity, Immunologic,
pubmed-meshheading:12745270-DNA Fragmentation,
pubmed-meshheading:12745270-Doxorubicin,
pubmed-meshheading:12745270-Drug Resistance, Neoplasm,
pubmed-meshheading:12745270-Granzymes,
pubmed-meshheading:12745270-HLA Antigens,
pubmed-meshheading:12745270-Histocompatibility Antigens Class I,
pubmed-meshheading:12745270-Humans,
pubmed-meshheading:12745270-Killer Cells, Natural,
pubmed-meshheading:12745270-Leukemia, T-Cell,
pubmed-meshheading:12745270-Lysosomes,
pubmed-meshheading:12745270-Poly(ADP-ribose) Polymerases,
pubmed-meshheading:12745270-Serine Endopeptidases,
pubmed-meshheading:12745270-Tumor Cells, Cultured,
pubmed-meshheading:12745270-Up-Regulation
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pubmed:year |
2003
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pubmed:articleTitle |
Natural killer resistance of a drug-resistant leukemia cell line, mediated by up-regulation of HLA class I expression.
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pubmed:affiliation |
University Children's Hospital Ulm, Prittwitzstrasse 43, D-89070 Ulm, Germany. carl.classen@medizin.uni-ulm.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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