Linked Life Data

12744467

Source:http://linkedlifedata.com/resource/pubmed/id/12744467

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-5-14
pubmed:abstractText
No data exist on angiogenic patterns and their prognostic impact in human glioblastoma. Such data are relevant for translation of antiangiogenic therapies into clinical applications. Using immunohistochemistry for CD34, we assessed vascular patterns in 114 primary glioblastomas. Vascular patterns comprised unevenly distributed glomeruloid/garland-like/clustered bizarre vascular formations and evenly distributed delicate capillary-like microvessels ("classic" vascular pattern). The combination of low content of bizarre vascular formations and prominent classic vascular pattern (n=29) was an independent factor for longer survival (p=0.006, Cox regression), as well as postoperative high Karnofsky performance status (p=0.005). In patients with a prominent classic vascular pattern, there was no difference of MIB1 labeling index whereas microvessel density and apoptotic index (TUNEL) were significantly higher as compared to all other patients (p<0.05). In addition, diffuse expression of hypoxia-inducible factor (HIF)-1alpha and strong expression of vascular endothelial growth factor were more common (p<0.05, Chi-square test). FISH revealed loss of chromosomes 1p and 19q only in 1/7 long-time survivors with classic pattern. We conclude that vascular patterns in primary glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins. Our findings denote for the first time distinct angiogenic subtypes of human glioblastoma which may prove relevant for anti-angiogenic therapy approaches.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1015-6305
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
133-43
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12744467-Adult, pubmed-meshheading:12744467-Aged, pubmed-meshheading:12744467-Antigens, CD34, pubmed-meshheading:12744467-Brain Neoplasms, pubmed-meshheading:12744467-Endothelial Growth Factors, pubmed-meshheading:12744467-Glioblastoma, pubmed-meshheading:12744467-Humans, pubmed-meshheading:12744467-Hypoxia-Inducible Factor 1, alpha Subunit, pubmed-meshheading:12744467-Immunohistochemistry, pubmed-meshheading:12744467-In Situ Nick-End Labeling, pubmed-meshheading:12744467-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:12744467-Ki-67 Antigen, pubmed-meshheading:12744467-Lymphokines, pubmed-meshheading:12744467-Middle Aged, pubmed-meshheading:12744467-Neovascularization, Pathologic, pubmed-meshheading:12744467-Survival Analysis, pubmed-meshheading:12744467-Tissue Distribution, pubmed-meshheading:12744467-Transcription Factors, pubmed-meshheading:12744467-Vascular Endothelial Growth Factor A, pubmed-meshheading:12744467-Vascular Endothelial Growth Factors
pubmed:year
2003
pubmed:articleTitle
Vascular patterns in glioblastoma influence clinical outcome and associate with variable expression of angiogenic proteins: evidence for distinct angiogenic subtypes.
pubmed:affiliation
Institute of Clinical Pathology, University of Vienna, Austria.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't