Linked Life Data

12741681

Source:http://linkedlifedata.com/resource/pubmed/id/12741681

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2003-5-13
pubmed:abstractText
Melanoma cells but not normal melanocytes share important cell surface molecules with endothelial cells. From this observation has grown our hypothesis that melanoma and endothelial cells use the same cell surface molecules for invasion but that their intracellular signaling is different allowing the malignant cells dominance over the normal cells. Stromal fibroblasts and endothelial cells communicate with metastatic cells through an interactive network of cell-cell and cell-matrix signaling. Fibroblasts induce capillary-like differentiation of microvascular endothelial cell monolayers through cell-cell contact and soluble factors. It is then hypothesized that normal cellular precursors are recruited from the bone marrow to the site of a growing melanoma metastasis. Thus pathways for angiogenesis and vasculogenesis are guided through the cooperation of fibroblasts and melanoma cells perpetuated by the dominance of the metastatic melanoma cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
0262-0898
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
229-35
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
The vascular phenotype of melanoma metastasis.
pubmed:affiliation
The Wistar Institute, Philadelphia, Pennsylvania 19104, USA.
pubmed:publicationType
Journal Article, Review