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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-5-28
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pubmed:abstractText |
Fear conditioning involves the induction of long-term potentiation (LTP) of excitatory synaptic transmission in the lateral amygdala, a brain structure which is tightly controlled by GABAergic inhibition. Here we show that dopamine gates the induction of LTP in the mouse lateral amygdala by suppressing feedforward inhibition from local interneurons. Our findings provide a cellular mechanism for the dopaminergic modulation of fear conditioning and indicate that suppression of feedforward inhibition represents a key mechanism for the induction of associative synaptic plasticity in the lateral amygdala.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1097-6256
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
587-92
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12740581-Amygdala,
pubmed-meshheading:12740581-Animals,
pubmed-meshheading:12740581-Conditioning (Psychology),
pubmed-meshheading:12740581-Dopamine,
pubmed-meshheading:12740581-Dopamine Agonists,
pubmed-meshheading:12740581-Dopamine Antagonists,
pubmed-meshheading:12740581-Excitatory Postsynaptic Potentials,
pubmed-meshheading:12740581-Fear,
pubmed-meshheading:12740581-GABA Antagonists,
pubmed-meshheading:12740581-Interneurons,
pubmed-meshheading:12740581-Learning,
pubmed-meshheading:12740581-Long-Term Potentiation,
pubmed-meshheading:12740581-Male,
pubmed-meshheading:12740581-Mice,
pubmed-meshheading:12740581-Mice, Inbred C57BL,
pubmed-meshheading:12740581-Neural Inhibition,
pubmed-meshheading:12740581-Neural Pathways,
pubmed-meshheading:12740581-Organ Culture Techniques,
pubmed-meshheading:12740581-Receptors, Dopamine,
pubmed-meshheading:12740581-Synaptic Transmission,
pubmed-meshheading:12740581-gamma-Aminobutyric Acid
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pubmed:year |
2003
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pubmed:articleTitle |
Dopamine gates LTP induction in lateral amygdala by suppressing feedforward inhibition.
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pubmed:affiliation |
Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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