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pubmed:abstractText |
Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.
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pubmed:affiliation |
Departments of Psychology and Neurology, and ARL Division of Neural Systems, Memory and Aging, University of Arizona, Tucson, AZ 85724, USA. carol@nsma.arizona.edu
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