|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2003-5-9
|
|
pubmed:abstractText |
Maternal diabetes increases oxidative stress in embryos. Maternal diabetes also inhibits expression of embryonic genes, most notably, Pax-3, which is required for neural tube closure. Here we tested the hypothesis that oxidative stress inhibits expression of Pax-3, thereby providing a molecular basis for neural tube defects induced by diabetic pregnancy.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimycin A,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Pax3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Tocopherol
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0012-186X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
46
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
538-45
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:12739027-Animals,
pubmed-meshheading:12739027-Antimycin A,
pubmed-meshheading:12739027-Cells, Cultured,
pubmed-meshheading:12739027-DNA-Binding Proteins,
pubmed-meshheading:12739027-Diabetes Mellitus, Experimental,
pubmed-meshheading:12739027-Embryo, Mammalian,
pubmed-meshheading:12739027-Embryonal Carcinoma Stem Cells,
pubmed-meshheading:12739027-Embryonic and Fetal Development,
pubmed-meshheading:12739027-Female,
pubmed-meshheading:12739027-Gene Expression Regulation, Developmental,
pubmed-meshheading:12739027-Mice,
pubmed-meshheading:12739027-Mice, Inbred ICR,
pubmed-meshheading:12739027-Neoplastic Stem Cells,
pubmed-meshheading:12739027-Neural Tube Defects,
pubmed-meshheading:12739027-Oxidants,
pubmed-meshheading:12739027-Oxidative Stress,
pubmed-meshheading:12739027-Paired Box Transcription Factors,
pubmed-meshheading:12739027-Pregnancy,
pubmed-meshheading:12739027-Pregnancy in Diabetics,
pubmed-meshheading:12739027-RNA, Messenger,
pubmed-meshheading:12739027-Reactive Oxygen Species,
pubmed-meshheading:12739027-Transcription Factors,
pubmed-meshheading:12739027-alpha-Tocopherol
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Oxidant regulation of gene expression and neural tube development: Insights gained from diabetic pregnancy on molecular causes of neural tube defects.
|
|
pubmed:affiliation |
Section on Molecular Biology and Complications, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
