rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-6-6
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pubmed:abstractText |
Kappa-opioid receptors (KOR) have been implicated in neuroprotection from ischemic neuronal injury. We tested the effects of a selective and specific KOR agonist, BRL 52537 hydrochloride [(+/-)-1-(3,4-dichlorophenyl)acetyl-2-(1-pyrrolidinyl) methylpiperidine], on infarct volume and nitric oxide production after transient focal ischemia in the rat.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1-(3,4-dichlorophenyl)acetyl-2-(1-py...,
http://linkedlifedata.com/resource/pubmed/chemical/Arginine,
http://linkedlifedata.com/resource/pubmed/chemical/Citrulline,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Piperidines,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, kappa
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1524-4628
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1533-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12738895-Animals,
pubmed-meshheading:12738895-Arginine,
pubmed-meshheading:12738895-Cerebral Infarction,
pubmed-meshheading:12738895-Citrulline,
pubmed-meshheading:12738895-Corpus Striatum,
pubmed-meshheading:12738895-Disease Models, Animal,
pubmed-meshheading:12738895-Ischemic Attack, Transient,
pubmed-meshheading:12738895-Male,
pubmed-meshheading:12738895-Microdialysis,
pubmed-meshheading:12738895-Neuroprotective Agents,
pubmed-meshheading:12738895-Nitric Oxide,
pubmed-meshheading:12738895-Piperidines,
pubmed-meshheading:12738895-Pyrrolidines,
pubmed-meshheading:12738895-Rats,
pubmed-meshheading:12738895-Rats, Wistar,
pubmed-meshheading:12738895-Receptors, Opioid, kappa,
pubmed-meshheading:12738895-Treatment Outcome
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pubmed:year |
2003
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pubmed:articleTitle |
Neuroprotective kappa-opioid receptor agonist BRL 52537 attenuates ischemia-evoked nitric oxide production in vivo in rats.
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pubmed:affiliation |
Department of Anesthesiology/Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Md, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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