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rdf:type |
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lifeskim:mentions |
umls-concept:C0011906,
umls-concept:C0012634,
umls-concept:C0022660,
umls-concept:C0025723,
umls-concept:C0086860,
umls-concept:C0442726,
umls-concept:C0521378,
umls-concept:C0525037,
umls-concept:C1511790,
umls-concept:C1705280,
umls-concept:C2827404
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pubmed:issue |
5
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pubmed:dateCreated |
2003-5-9
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pubmed:abstractText |
There is a need to enhance endobiliary cytotechniques by molecular marker lesions. This is of special significance for patients with primary sclerosing cholangitis, a disease predisposing for the development of cholangiocarcinoma. The INK4a/ADP ribosylation factor (ARF) locus encodes two tumor suppressor genes: p16INK4a and p14ARF. p16INK4a has been shown to be of major significance in cholangiocarcinoma.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1773-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12738733-Adult,
pubmed-meshheading:12738733-Aged,
pubmed-meshheading:12738733-Bile Duct Neoplasms,
pubmed-meshheading:12738733-Bile Ducts, Intrahepatic,
pubmed-meshheading:12738733-Cholangiocarcinoma,
pubmed-meshheading:12738733-Choledocholithiasis,
pubmed-meshheading:12738733-Cyclin-Dependent Kinase Inhibitor p16,
pubmed-meshheading:12738733-DNA, Neoplasm,
pubmed-meshheading:12738733-DNA Methylation,
pubmed-meshheading:12738733-Diagnosis, Differential,
pubmed-meshheading:12738733-Gallbladder Diseases,
pubmed-meshheading:12738733-Gene Silencing,
pubmed-meshheading:12738733-Humans,
pubmed-meshheading:12738733-Middle Aged,
pubmed-meshheading:12738733-Prognosis,
pubmed-meshheading:12738733-Promoter Regions, Genetic,
pubmed-meshheading:12738733-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12738733-Survival Rate,
pubmed-meshheading:12738733-Tumor Markers, Biological,
pubmed-meshheading:12738733-Tumor Suppressor Protein p14ARF
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pubmed:year |
2003
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pubmed:articleTitle |
Promoter methylation of INK4a/ARF as detected in bile-significance for the differential diagnosis in biliary disease.
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pubmed:affiliation |
Department of Internal Medicine I, University Hospital of Tübingen, Germany. bodo.klump@med.uni-tuebingen.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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