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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-5-9
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pubmed:abstractText |
Previous studies have shown that a specific 9-mer amino acid epitope (designated CAP-1) of the human "self" tumor-associated carcinoembryonic antigen can be used to stimulate CD8+ T cells from peripheral blood mononuclear cells of carcinoma patients vaccinated with pox vector-based carcinoembryonic antigen vaccines. A T-cell receptor agonist epitope of CAP-1 (designated CAP1-6D) has been shown to enhance the stimulation of T cells over levels obtained using CAP-1. The purpose of this study was to analyze gene expression profiles in T cells stimulated with the native CAP-1 versus the agonist CAP1-6D peptide.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinoembryonic Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, C,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/XCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/lymphotactin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1616-27
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12738714-Antigens, Neoplasm,
pubmed-meshheading:12738714-CD8-Positive T-Lymphocytes,
pubmed-meshheading:12738714-Carcinoembryonic Antigen,
pubmed-meshheading:12738714-Chemokines, C,
pubmed-meshheading:12738714-Colonic Neoplasms,
pubmed-meshheading:12738714-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:12738714-Epitopes, T-Lymphocyte,
pubmed-meshheading:12738714-Gene Expression Profiling,
pubmed-meshheading:12738714-Humans,
pubmed-meshheading:12738714-Lymphokines,
pubmed-meshheading:12738714-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:12738714-Peptide Fragments,
pubmed-meshheading:12738714-RNA, Messenger,
pubmed-meshheading:12738714-RNA, Neoplasm,
pubmed-meshheading:12738714-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:12738714-Sialoglycoproteins,
pubmed-meshheading:12738714-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:12738714-Tumor Cells, Cultured
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pubmed:year |
2003
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pubmed:articleTitle |
Differential gene expression profiles in a human T-cell line stimulated with a tumor-associated self-peptide versus an enhancer agonist peptide.
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pubmed:affiliation |
Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study
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