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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2003-5-8
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pubmed:abstractText |
Extrahepatic bile duct carcinoma (EBDC) is a malignancy well known for its poor prognosis. Some clinicopathological prognostic markers have been proposed, but genetic factors have not been well investigated. We have examined expression patterns of caveolin-1, which has been shown to function as a tumour suppressor in vitro, in EBDC using immunohistochemistry. Normal tissues adjacent to the tumour cells did not show immunoreactivity for caveolin-1. A total of 22 of the 60-carcinoma tissue samples (36.7%) studied were positive for caveolin-1. Caveolin-1 immunostaining negatively correlated with the patient's age and pathological T factor (pT) in a statistically significant manner. Multivariate analysis using Cox's proportional hazards model identified caveolin-1 expression as an independent positive prognostic factor. Thus, our study suggests that caveolin-1 expression may be a useful prognostic marker for EBDC.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0920
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pubmed:author |
pubmed-author:ChuCC,
pubmed-author:FukunagaAA,
pubmed-author:HidaYY,
pubmed-author:HiraokaKK,
pubmed-author:KatoKK,
pubmed-author:KatohHH,
pubmed-author:KondoSS,
pubmed-author:KurokawaTT,
pubmed-author:LUNTM RMR,
pubmed-author:MiyamotoMM,
pubmed-author:MorikawaTT,
pubmed-author:MurakamiSS,
pubmed-author:NakakuboYY,
pubmed-author:OkushibaOO,
pubmed-author:OshikiriTT,
pubmed-author:ShinoharaTT,
pubmed-author:SuzuokiMM
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
88
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1234-8
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:12737162-Adult,
pubmed-meshheading:12737162-Aged,
pubmed-meshheading:12737162-Aged, 80 and over,
pubmed-meshheading:12737162-Bile Duct Neoplasms,
pubmed-meshheading:12737162-Bile Ducts, Extrahepatic,
pubmed-meshheading:12737162-Carcinoma,
pubmed-meshheading:12737162-Caveolin 1,
pubmed-meshheading:12737162-Caveolins,
pubmed-meshheading:12737162-Female,
pubmed-meshheading:12737162-Humans,
pubmed-meshheading:12737162-Immunohistochemistry,
pubmed-meshheading:12737162-Lymphatic Metastasis,
pubmed-meshheading:12737162-Male,
pubmed-meshheading:12737162-Middle Aged,
pubmed-meshheading:12737162-Neovascularization, Pathologic,
pubmed-meshheading:12737162-Prognosis,
pubmed-meshheading:12737162-Survival Analysis,
pubmed-meshheading:12737162-Time Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Caveolin-I overexpression is a favourable prognostic factor for patients with extrahepatic bile duct carcinoma.
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pubmed:affiliation |
Department of Surgical Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
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pubmed:publicationType |
Journal Article
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