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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2003-5-8
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pubmed:abstractText |
Cyclooxygenase-2 (COX-2) expression and peroxisome proliferator-activated receptor-gamma (PPARgamma) inactivation are linked to increased risk of human breast cancer. This study examines the effect of simultaneous targeting of COX-2 and PPARgamma on the proliferation of human breast cancer cells and on the expression of Bcl-2, BAX, and caspases-3 and -9, modulators of apoptotic cell death. Treatment of MDA-MB-231 breast cancer cells with NS-398 (a COX-2 inhibitor) or ciglitazone (CGZ, a PPARgamma-ligand) significantly inhibited cell proliferation and markedly increased apoptotic rates. These effects were accompanied by upregulation of BAX and caspases-3 and -9 mRNA expression and downregulation of Bcl-2. Compared to the influence of separate treatments, simultaneous treatment with NS-398 and CGZ synergistically inhibited cell proliferation and induced apoptotic cell death. In conclusion, combinational targeting of COX-2 and PPARgamma can inhibit the growth of human breast cancer cells and induce apoptosis to an extent more suprior to that produced by targeting each molecule alone. COX-2 and PPARgamma can be promising molecular targets for combinational chemoprevention or treatment of breast cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BAX protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/N-(2-cyclohexyloxy-4-nitrophenyl)met...,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cytoplasmic and Nuclear,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazolidinediones,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/bcl-2-Associated X Protein,
http://linkedlifedata.com/resource/pubmed/chemical/ciglitazone
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1107-3756
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12736714-Apoptosis,
pubmed-meshheading:12736714-Breast Neoplasms,
pubmed-meshheading:12736714-Caspase 3,
pubmed-meshheading:12736714-Caspases,
pubmed-meshheading:12736714-Cell Cycle,
pubmed-meshheading:12736714-Cell Division,
pubmed-meshheading:12736714-Cell Line, Tumor,
pubmed-meshheading:12736714-Cyclooxygenase 2,
pubmed-meshheading:12736714-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:12736714-Cyclooxygenase Inhibitors,
pubmed-meshheading:12736714-Female,
pubmed-meshheading:12736714-Gene Expression,
pubmed-meshheading:12736714-Genes, bcl-2,
pubmed-meshheading:12736714-Humans,
pubmed-meshheading:12736714-Isoenzymes,
pubmed-meshheading:12736714-Membrane Proteins,
pubmed-meshheading:12736714-Nitrobenzenes,
pubmed-meshheading:12736714-Prostaglandin-Endoperoxide Synthases,
pubmed-meshheading:12736714-Proto-Oncogene Proteins,
pubmed-meshheading:12736714-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:12736714-RNA, Messenger,
pubmed-meshheading:12736714-RNA, Neoplasm,
pubmed-meshheading:12736714-Receptors, Cytoplasmic and Nuclear,
pubmed-meshheading:12736714-Sulfonamides,
pubmed-meshheading:12736714-Thiazolidinediones,
pubmed-meshheading:12736714-Transcription Factors,
pubmed-meshheading:12736714-bcl-2-Associated X Protein
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pubmed:year |
2003
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pubmed:articleTitle |
Inhibition of cyclooxygenase-2 and activation of peroxisome proliferator-activated receptor-gamma synergistically induces apoptosis and inhibits growth of human breast cancer cells.
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pubmed:affiliation |
Novexpharma, Richmond Hills, ON L4C 5H2, Canada.
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pubmed:publicationType |
Journal Article
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