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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-5-8
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pubmed:abstractText |
Transgene expression and skin tumorigenicity were investigated in transgenic TG-AC mice carrying the v-Ha-ras after treatment with benzo[a]pyrene (BP). Animals treated with 40 microg BP (x2/week/mouse) showed 100% tumor response after 25 weeks, as did 40% of the mice treated with 20 microg BP but 10 microg BP did not produce a tumor response. In the case of animals treated with 40 microg BP for 25 weeks, most of the tumors were proven to be carcinomas (80%, 4 out of 5 mice), and all tumors were shown to be positive in terms of transgene expression detected by in situ hybridization. These data suggest that BP was tumorigenic in a dose-dependent manner in TG-AC mice and that TG-AC mice were dependent on transgene expression during BP carcinogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0918-6158
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pubmed:author |
pubmed-author:AhnMi YoungMY,
pubmed-author:BaeHye JinHJ,
pubmed-author:ChoMyung HaingMH,
pubmed-author:ChoiSul MinSM,
pubmed-author:ChunSun AhSA,
pubmed-author:HanSoon YoungSY,
pubmed-author:KimHyung SikHS,
pubmed-author:KimIn SunIS,
pubmed-author:KimKyu BongKB,
pubmed-author:KwackSeung JunSJ,
pubmed-author:LeeByung MuBM,
pubmed-author:LeeKyung RimKR,
pubmed-author:ParkKui LaeKL,
pubmed-author:ParkYo AnYA,
pubmed-author:SongHyun SueHS,
pubmed-author:YooSun DongSD
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-5
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pubmed:dateRevised |
2005-11-17
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pubmed:meshHeading |
pubmed-meshheading:12736523-Animals,
pubmed-meshheading:12736523-Benzo(a)pyrene,
pubmed-meshheading:12736523-Carcinogens,
pubmed-meshheading:12736523-Carcinoma,
pubmed-meshheading:12736523-Female,
pubmed-meshheading:12736523-In Situ Hybridization,
pubmed-meshheading:12736523-Mice,
pubmed-meshheading:12736523-Mice, Transgenic,
pubmed-meshheading:12736523-Skin Neoplasms,
pubmed-meshheading:12736523-Transgenes,
pubmed-meshheading:12736523-ras Proteins
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pubmed:year |
2003
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pubmed:articleTitle |
Ras transgene expression in TG-AC mice treated with benzo[a]pyrene.
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pubmed:affiliation |
Division of Toxicology, College of Pharmacy, SungKyunKwan University, Chunchun-dong, Suwon, Kyonggi-do, South Korea. bmlee@skku.ac.kr
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pubmed:publicationType |
Journal Article
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