Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2003-5-6
pubmed:abstractText
A total of 30 multiple myeloma patients (M=23, F=7; age 31-55 years, median 48) were allografted with peripheral blood stem cells (PBSC) from HLA-identical siblings. Time to transplantation was 3-107 months (median 8). Prior chemotherapy lines varied from 1 to 6 (median 1). Four patients were in complete remission (CR), 11 in partial remission (PR), 13 were considered to be nonresponders, and two had progressive disease. Most were conditioned with busulfan-melphalan. PBSC were collected by apheresis after G-CSF or sequential GM-CSF and G-CSF. The patients were grafted with 4.4-24.1 x 10(6)/kg CD34+ (median 7.9) and 0.9-7.9 x 10(8)/kg CD3+ cells (median 2.3). GVHD prophylaxis was methotrexate-cyclosporine. Engraftment was complete and rapid. Grades II-IV acute GVHD (aGVHD) developed in 16 (53%), but was grade III-IV only in five (17%); chronic GVHD (cGVHD) developed in 17 out of the 24 evaluable patients (71%). A total of 18 patients (71%) attained CR after transplantation. TRM was 30% overall, 16% at 100 days. There was only one relapse. Overall survival and event-free survival at 73 months were 60% and 67%, respectively. PCR negativity for IgH-gene rearrangement occurred in all persistently CR patients studied. PBSC allograft can induce long remissions, because of profound suppression of the neoplastic clone that is probably linked to the antitumor effect of cGVHD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0268-3369
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
767-73
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12732883-Adult, pubmed-meshheading:12732883-Antigens, CD3, pubmed-meshheading:12732883-Antigens, CD34, pubmed-meshheading:12732883-Female, pubmed-meshheading:12732883-Graft Survival, pubmed-meshheading:12732883-Graft vs Host Disease, pubmed-meshheading:12732883-Graft vs Tumor Effect, pubmed-meshheading:12732883-Humans, pubmed-meshheading:12732883-Male, pubmed-meshheading:12732883-Middle Aged, pubmed-meshheading:12732883-Multiple Myeloma, pubmed-meshheading:12732883-Neoplasm, Residual, pubmed-meshheading:12732883-Peripheral Blood Stem Cell Transplantation, pubmed-meshheading:12732883-Recurrence, pubmed-meshheading:12732883-Remission Induction, pubmed-meshheading:12732883-Siblings, pubmed-meshheading:12732883-Survival Analysis, pubmed-meshheading:12732883-Transplantation, Homologous, pubmed-meshheading:12732883-Transplantation, Isogeneic
pubmed:year
2003
pubmed:articleTitle
High rate of remission and low rate of disease recurrence in patients with multiple myeloma allografted with PBSC from their HLA-identical sibling donors.
pubmed:affiliation
Hematology and Bone Marrow Transplantation Unit, Azienda Ospedaliera S.Camillo-Forlanini, Roma, Italy. imajolino@libero.it
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't