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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-5-6
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pubmed:abstractText |
Chronic inflammation contributes to carcinogenesis, but the underlying mechanisms are poorly understood. We report that aged granulocyte-macrophage colony stimulating factor (GM-CSF)-deficient mice develop a systemic lupus erythematosis (SLE)-like disorder associated with the impaired phagocytosis of apoptotic cells. Concurrent deficiency of interferon (IFN)-gamma attenuates the SLE, but promotes the formation of diverse hematologic and solid neoplasms within a background of persistent infection and inflammation. Whereas activated B cells show a resistance to fas-induced apoptosis, antimicrobial therapy prevents lymphomagenesis and solid tumor development. These findings demonstrate that the interplay of infectious agents with cytokine-mediated regulation of immune homeostasis is a critical determinant of cancer susceptibility.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10051625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10071343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10559454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10562311,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10786799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10934224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10971784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-10987669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11101867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11133760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11159518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11239450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11385500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11449278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11449279,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11526388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-11672538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-12045246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-12093877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-2215606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-3498446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-7777494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-8097319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-8171324,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-8456300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-8625515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-9356488,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-9435308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-9607923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12732663-9636188
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
197
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1213-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2003
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pubmed:articleTitle |
Deficiencies of GM-CSF and interferon gamma link inflammation and cancer.
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pubmed:affiliation |
Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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