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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
18
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pubmed:dateCreated |
2003-5-13
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pubmed:abstractText |
Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs vasodilation by a low-density lipoprotein (LDL)-dependent mechanism. SCD has been characterized as a chronic state of inflammation in which xanthine oxidase (XO) from ischemic tissues increases vascular superoxide anion (O2*-) generation. Recent reports indicate that apolipoprotein (apo) A-1 mimetics inhibit atherosclerosis in LDL receptor-null (Ldlr-/-) mice fed Western diets. Here we hypothesize that L-4F, an apoA-1 mimetic, preserves vasodilation in hypercholesterolemia and SCD by decreasing mechanisms that increase O2*- generation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:AckermanAllan WAW,
pubmed-author:GuiceKarenK,
pubmed-author:GuttermanDavid DDD,
pubmed-author:HatoumOssama AOA,
pubmed-author:HilleryCheryl ACA,
pubmed-author:HolzhauerSandraS,
pubmed-author:JonesDeron WDW,
pubmed-author:OldhamKeith TKT,
pubmed-author:OuJingsongJ,
pubmed-author:OuZhijunZ,
pubmed-author:PritchardKirkwood AKAJr,
pubmed-author:WeihrauchDorothee WDW
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2337-41
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:12732610-Anemia, Sickle Cell,
pubmed-meshheading:12732610-Animals,
pubmed-meshheading:12732610-Apolipoprotein A-I,
pubmed-meshheading:12732610-Arterioles,
pubmed-meshheading:12732610-Cells, Cultured,
pubmed-meshheading:12732610-Endothelium, Vascular,
pubmed-meshheading:12732610-Hypercholesterolemia,
pubmed-meshheading:12732610-Male,
pubmed-meshheading:12732610-Mice,
pubmed-meshheading:12732610-Mice, Inbred C57BL,
pubmed-meshheading:12732610-Mice, Knockout,
pubmed-meshheading:12732610-Molecular Mimicry,
pubmed-meshheading:12732610-Peptides,
pubmed-meshheading:12732610-Receptors, LDL,
pubmed-meshheading:12732610-Superoxides,
pubmed-meshheading:12732610-Vasodilation
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pubmed:year |
2003
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pubmed:articleTitle |
L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease.
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pubmed:affiliation |
Division of Pediatric Surgery, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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