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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1976-8-2
|
| pubmed:abstractText |
The effects of chlorpromazine on the acquisition of a brightness discrimination with food reward were examined. Doses of 0.5, 1.0 or 2.0 mg/kg of CPZ as well as saline were administered intraperitoneally to 4 groups of 7 Sprague-Dawley rats, 1 h prior to testing. After a 3-week period of habituation and pre-training, rats were tested 20 trials a day, 7 days a week. No drug effect was found on the number of trials to reach a criterion of 18/20 successive correct responses, which required an average of 6.2 days of training. Precriterion latencies, however, showed an increase as a function of increasing dose level. Post-choice latencies were not affected, eliminating motor retardation as an explanation for the latency effect.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0033-3158
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
28
|
| pubmed:volume |
47
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
205-8
|
| pubmed:dateRevised |
2003-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:1273219-Animals,
pubmed-meshheading:1273219-Chlorpromazine,
pubmed-meshheading:1273219-Discrimination Learning,
pubmed-meshheading:1273219-Dose-Response Relationship, Drug,
pubmed-meshheading:1273219-Male,
pubmed-meshheading:1273219-Motor Activity,
pubmed-meshheading:1273219-Rats,
pubmed-meshheading:1273219-Reaction Time
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Effects of low and moderate doses of chlorpromazine on discrimination learning in the rat.
|
| pubmed:publicationType |
Journal Article
|