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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2003-5-5
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pubmed:abstractText |
Uncontrolled T-cell activation plays a critical role in the pathogenesis of inflammatory bowel diseases. Therefore, pharmacologic strategies directed to restore the normal responsiveness of the immune system by deleting inappropriately activated T cells could be efficacious in the treatment of these pathologic conditions. Galectin-1 is an endogenous lectin expressed in lymphoid organs that plays a role in the maintenance of central and peripheral tolerance. The aim of the present study was to evaluate the therapeutic effects of galectin-1 on T-helper cell type 1-mediated experimental colitis induced by intrarectal administration of 2,4,6-trinitrobenzene sulfonic acid (TNBS) in mice.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
124
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1381-94
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12730878-Animals,
pubmed-meshheading:12730878-CD4-Positive T-Lymphocytes,
pubmed-meshheading:12730878-Colitis,
pubmed-meshheading:12730878-Disease Models, Animal,
pubmed-meshheading:12730878-Galectin 1,
pubmed-meshheading:12730878-Gene Expression,
pubmed-meshheading:12730878-Interferon-gamma,
pubmed-meshheading:12730878-Interleukin-1,
pubmed-meshheading:12730878-Interleukin-12,
pubmed-meshheading:12730878-Mice,
pubmed-meshheading:12730878-Mice, Inbred BALB C,
pubmed-meshheading:12730878-Recombinant Proteins,
pubmed-meshheading:12730878-Spleen,
pubmed-meshheading:12730878-Trinitrobenzenesulfonic Acid,
pubmed-meshheading:12730878-Tumor Necrosis Factor-alpha
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pubmed:year |
2003
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pubmed:articleTitle |
Galectin-1 suppresses experimental colitis in mice.
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pubmed:affiliation |
Dipartmento di Science Chirurgiche, Gastroenterologiche ed Epatologiche, Universit? degli Studi di Perugia, Italy. lsant@unipg.it
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pubmed:publicationType |
Journal Article
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