Linked Life Data

12730245

Source:http://linkedlifedata.com/resource/pubmed/id/12730245

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-5-5
pubmed:abstractText
Human thoracic discs were analyzed for collagen and collagen cross-links to determine the distribution due to segmental, age, and gender influences. Thoracic discs from 26 cadaveric spines (1 to 90 years old) were graded macroscopically, then separated into anular and nuclear samples. Only grade I (i.e., normal) disc samples were selected (n=209). Pyridinoline and deoxypyridinoline cross-links were initially separated by column chromatography and analyzed by reverse-phase high-pressure liquid chromatography. The collagen content was lower and the extent of pyridinoline and deoxypyridinoline were significantly higher in the nucleus compared with the anulus (p <.001). The collagen content and extent of pyridinoline were significantly lower with increasing age in the anulus and nucleus (p <.001). Young male discs had a significantly higher extent of pyridinoline compared with females (p <.001). Age, gender, and disc region differences were found to have a significant influence on the biochemical composition of the normal disc extracellular matrix.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1079-5006
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
B387-93
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Age-related changes in collagen, pyridinoline, and deoxypyridinoline in normal human thoracic intervertebral discs.
pubmed:affiliation
Centre for Musculoskeletal Studies, Department of Surgery, University of Western Australia, Royal Perth Hospital, Murray Street, Perth, WA 6000, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't