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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2003-5-5
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pubmed:abstractText |
We studied the role of Rho kinase and extracellular signal-regulated kinase (ERK)-2 in the polarization and migration of T lymphocytes in response to the CCR7 ligands EBI1 ligand chemokine (ELC; CCL19) and secondary lymphoid-tissue chemokine (SLC; CCL21). Both Rho kinase protein isoforms are expressed in T lymphocytes. Inhibition of the Rho kinases with Y-27632 strongly inhibited SLC- and ELC-induced polarized morphology and chemotaxis of T lymphocytes. Although the chemokines induced ERK-2 activation, the blockade of this signaling pathway showed no effect on polarization and migration. This study indicates an important role of Rho kinase in CCR7-mediated polarization and migration of T lymphocytes, whereas ERK-2 is not involved in these processes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Pyridines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine,
http://linkedlifedata.com/resource/pubmed/chemical/Y 27632,
http://linkedlifedata.com/resource/pubmed/chemical/rho-Associated Kinases
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
8
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pubmed:volume |
542
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
79-83
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12729902-Amides,
pubmed-meshheading:12729902-Cell Polarity,
pubmed-meshheading:12729902-Cells, Cultured,
pubmed-meshheading:12729902-Chemokines,
pubmed-meshheading:12729902-Chemotaxis, Leukocyte,
pubmed-meshheading:12729902-Enzyme Inhibitors,
pubmed-meshheading:12729902-Humans,
pubmed-meshheading:12729902-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:12729902-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:12729902-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12729902-Pyridines,
pubmed-meshheading:12729902-Receptors, CCR7,
pubmed-meshheading:12729902-Receptors, Chemokine,
pubmed-meshheading:12729902-T-Lymphocytes,
pubmed-meshheading:12729902-rho-Associated Kinases
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pubmed:year |
2003
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pubmed:articleTitle |
Rho kinase is required for CCR7-mediated polarization and chemotaxis of T lymphocytes.
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pubmed:affiliation |
Theodor Kocher Institute, P.O. Box, CH-3000 9 Bern, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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