| pubmed-article:12729652 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12729652 | lifeskim:mentions | umls-concept:C0002771 | lld:lifeskim |
| pubmed-article:12729652 | lifeskim:mentions | umls-concept:C0036140 | lld:lifeskim |
| pubmed-article:12729652 | lifeskim:mentions | umls-concept:C0037494 | lld:lifeskim |
| pubmed-article:12729652 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:12729652 | lifeskim:mentions | umls-concept:C0038477 | lld:lifeskim |
| pubmed-article:12729652 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:12729652 | lifeskim:mentions | umls-concept:C1710548 | lld:lifeskim |
| pubmed-article:12729652 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12729652 | pubmed:dateCreated | 2003-5-5 | lld:pubmed |
| pubmed-article:12729652 | pubmed:abstractText | Three series of spirocyclopiperazinium derivatives 5a-d, 6a-f and 17a-d were synthesized and evaluated for their in vivo analgesic activities. Compounds 5a, 17a and 17b exhibited excellent analgesic activity. Two important structure-activity relationships were observed from this study: (1) the quaternary ammonium functionality is a critical pharmacophore for analgesic activity; (2) it is important to adjust the lipophilic property of compounds to improve analgesic activity. | lld:pubmed |
| pubmed-article:12729652 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12729652 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12729652 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12729652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12729652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12729652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12729652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12729652 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12729652 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12729652 | pubmed:month | May | lld:pubmed |
| pubmed-article:12729652 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:12729652 | pubmed:author | pubmed-author:VigoC BCB | lld:pubmed |
| pubmed-article:12729652 | pubmed:author | pubmed-author:ChengTie-Ming... | lld:pubmed |
| pubmed-article:12729652 | pubmed:author | pubmed-author:GaoFeng-LiFL | lld:pubmed |
| pubmed-article:12729652 | pubmed:author | pubmed-author:LiRun-TaoRT | lld:pubmed |
| pubmed-article:12729652 | pubmed:author | pubmed-author:PiaoHong-BinH... | lld:pubmed |
| pubmed-article:12729652 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12729652 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:12729652 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:12729652 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12729652 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12729652 | pubmed:pagination | 1729-32 | lld:pubmed |
| pubmed-article:12729652 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:meshHeading | pubmed-meshheading:12729652... | lld:pubmed |
| pubmed-article:12729652 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12729652 | pubmed:articleTitle | Unique spirocyclopiperazinium salt. Part 2: synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics. | lld:pubmed |
| pubmed-article:12729652 | pubmed:affiliation | School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China. | lld:pubmed |
| pubmed-article:12729652 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12729652 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:12729652 | lld:chembl |
