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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2003-5-5
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pubmed:abstractText |
Three series of spirocyclopiperazinium derivatives 5a-d, 6a-f and 17a-d were synthesized and evaluated for their in vivo analgesic activities. Compounds 5a, 17a and 17b exhibited excellent analgesic activity. Two important structure-activity relationships were observed from this study: (1) the quaternary ammonium functionality is a critical pharmacophore for analgesic activity; (2) it is important to adjust the lipophilic property of compounds to improve analgesic activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
19
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1729-32
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:12729652-Analgesics,
pubmed-meshheading:12729652-Animals,
pubmed-meshheading:12729652-Dose-Response Relationship, Drug,
pubmed-meshheading:12729652-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:12729652-Hypnotics and Sedatives,
pubmed-meshheading:12729652-Maximum Tolerated Dose,
pubmed-meshheading:12729652-Mice,
pubmed-meshheading:12729652-Piperazines,
pubmed-meshheading:12729652-Salts,
pubmed-meshheading:12729652-Spiro Compounds,
pubmed-meshheading:12729652-Structure-Activity Relationship
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pubmed:year |
2003
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pubmed:articleTitle |
Unique spirocyclopiperazinium salt. Part 2: synthesis and structure-activity relationship of dispirocyclopiperazinium salts as analgesics.
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pubmed:affiliation |
School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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