12729631

Source:http://linkedlifedata.com/resource/pubmed/id/12729631

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0443288, umls-concept:C1257954
pubmed:issue	10
pubmed:dateCreated	2003-5-5
pubmed:abstractText	A number of naphthofuranones were synthesized and tested for COX-1 and COX-2 inhibition. Few of them were identified as selective COX-2 inhibitors. Structure-activity relationship studies within the series are discussed.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 1, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Furans, http://linkedlifedata.com/resource/pubmed/chemical/Heterocyclic Compounds with 4 or..., http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes, http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins, http://linkedlifedata.com/resource/pubmed/chemical/PTGS1 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Prostaglandin-Endoperoxide Synthases
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0960-894X
pubmed:author	pubmed-author:MisraParimalP, pubmed-author:NagabelliMuraliM, pubmed-author:PalManojitM, pubmed-author:Rao CasturiSeshagiriS, pubmed-author:Rao KalledaSrinivasS, pubmed-author:Rao VeeramaneniVenugopalV, pubmed-author:Rao YeleswarapuKoteswarK
pubmed:issnType	Print
pubmed:day	19
pubmed:volume	13
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1639-43
pubmed:dateRevised	2005-11-17
pubmed:meshHeading	pubmed-meshheading:12729631-Cyclooxygenase 1, pubmed-meshheading:12729631-Cyclooxygenase 2, pubmed-meshheading:12729631-Cyclooxygenase 2 Inhibitors, pubmed-meshheading:12729631-Cyclooxygenase Inhibitors, pubmed-meshheading:12729631-Furans, pubmed-meshheading:12729631-Heterocyclic Compounds with 4 or More Rings, pubmed-meshheading:12729631-Humans, pubmed-meshheading:12729631-Inhibitory Concentration 50, pubmed-meshheading:12729631-Isoenzymes, pubmed-meshheading:12729631-Membrane Proteins, pubmed-meshheading:12729631-Molecular Conformation, pubmed-meshheading:12729631-Prostaglandin-Endoperoxide Synthases, pubmed-meshheading:12729631-Structure-Activity Relationship
pubmed:year	2003
pubmed:articleTitle	Conformationally restricted 3,4-diarylfuranones (2,3a,4,5-tetrahydronaphthofuranones) as selective cyclooxygenase-2 inhibitors.
pubmed:affiliation	Department of Chemistry, Discovery Research, Dr. Reddy's Laboratories Ltd., Bollaram Road, Miyapur, Hyderabad 500050, India. manojitpal@drreddys.com
pubmed:publicationType	Journal Article