Source:http://linkedlifedata.com/resource/pubmed/id/12727985
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
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| pubmed:dateCreated |
2003-5-2
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| pubmed:abstractText |
Lipolytic catecholamine resistance in sc fat cells is observed in polycystic ovarian syndrome (PCOS). The mechanisms behind this lipolysis defect were explored in vitro; sc fat cells were obtained from 10 young, nonobese PCOS women and from 14 matched, healthy control women. Fasting plasma glycerol levels were reduced by one third in PCOS (P < 0.05). Adipocytes of PCOS women were about 25% larger than in the controls (P < 0.05) and had 40% reduced noradrenaline-induced lipolysis (P < 0.05), which could be attributed to a 10-fold decreased beta(2)-adrenoceptor sensitivity (P < 0.05) and low ability of cAMP to activate the protein kinase A (PKA)/hormone-sensitive lipase (HSL) complex (P < 0.05). In PCOS, the adipocyte protein content of beta(2)-adrenoceptors, HSL, and the regulatory II beta-component of PKA were 70%, 55%, and 25% decreased, respectively (P < 0.001); but there was no change in the amount of the catalytic subunit of PKA or of beta(1)-adrenoceptors. Thus, lipolytic catecholamine resistance of sc adipocytes in PCOS is probably attributable to a combination of decreased amounts of beta(2)-adrenergic receptors, the regulatory II beta-component of PKA, and HSL. This may cause low in vivo lipolytic activity and enlarged sc fat cell size and promote later development of obesity in PCOS.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Glycerol,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/PRKAR2B protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2,
http://linkedlifedata.com/resource/pubmed/chemical/Sterol Esterase
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| pubmed:status |
MEDLINE
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| pubmed:month |
May
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| pubmed:issn |
0021-972X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
88
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2269-73
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| pubmed:dateRevised |
2007-11-15
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| pubmed:meshHeading |
pubmed-meshheading:12727985-Adipocytes,
pubmed-meshheading:12727985-Adult,
pubmed-meshheading:12727985-Catecholamines,
pubmed-meshheading:12727985-Cell Size,
pubmed-meshheading:12727985-Cyclic AMP,
pubmed-meshheading:12727985-Cyclic AMP-Dependent Protein Kinase RIIbeta Subunit,
pubmed-meshheading:12727985-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:12727985-Drug Resistance,
pubmed-meshheading:12727985-Enzyme Activation,
pubmed-meshheading:12727985-Fasting,
pubmed-meshheading:12727985-Female,
pubmed-meshheading:12727985-Glycerol,
pubmed-meshheading:12727985-Humans,
pubmed-meshheading:12727985-Lipolysis,
pubmed-meshheading:12727985-Norepinephrine,
pubmed-meshheading:12727985-Polycystic Ovary Syndrome,
pubmed-meshheading:12727985-Receptors, Adrenergic, beta-2,
pubmed-meshheading:12727985-Sterol Esterase
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| pubmed:year |
2003
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| pubmed:articleTitle |
Mechanisms behind lipolytic catecholamine resistance of subcutaneous fat cells in the polycystic ovarian syndrome.
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| pubmed:affiliation |
Department of Medicine, Huddinge University Hospital, Karolinska Institute, SE-141 86 Stockholm, Sweden.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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