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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-5-2
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pubmed:abstractText |
Characteristic of both chronic wounds and acute wounds that fail to heal are excessive leukocytosis and reduced matrix deposition. Estrogen is a major regulator of wound repair that can reverse age-related impaired wound healing in human and animal models, characterized by a dampened inflammatory response and increased matrix deposited at the wound site. Macrophage migration inhibitory factor (MIF) is a candidate proinflammatory cytokine involved in the hormonal regulation of inflammation. We demonstrate that MIF is upregulated in a distinct spatial and temporal pattern during wound healing and its expression is markedly elevated in wounds of estrogen-deficient mice as compared with intact animals. Wound-healing studies in mice rendered null for the MIF gene have demonstrated that in the absence of MIF, the excessive inflammation and delayed-healing phenotype associated with reduced estrogen is reversed. Moreover, in vitro assays have shown a striking estrogen-mediated decrease in MIF production by activated murine macrophages, a process involving the estrogen receptor. We suggest that estrogen inhibits the local inflammatory response by downregulating MIF, suggesting a specific target for future therapeutic intervention in impaired wound-healing states.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10064594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10099986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10514397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10559937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10564712,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10655104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10780884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-10809963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11014206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11017147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11121509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11150164,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11172683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11207663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11259268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11380688,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11445727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11501338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11553550,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11753049,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-11983005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-1217433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-14452479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-5576335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-5938421,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-8195715,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-8413654,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-8891436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-8913928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-9242648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-9348186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-9359694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-9367905,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-9501791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727922-9576065
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1309-18
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:12727922-Animals,
pubmed-meshheading:12727922-Down-Regulation,
pubmed-meshheading:12727922-Epidermis,
pubmed-meshheading:12727922-Estrogens,
pubmed-meshheading:12727922-Female,
pubmed-meshheading:12727922-Humans,
pubmed-meshheading:12727922-Lipopolysaccharides,
pubmed-meshheading:12727922-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:12727922-Macrophages,
pubmed-meshheading:12727922-Male,
pubmed-meshheading:12727922-Mice,
pubmed-meshheading:12727922-Mice, Inbred BALB C,
pubmed-meshheading:12727922-Mice, Knockout,
pubmed-meshheading:12727922-Ovariectomy,
pubmed-meshheading:12727922-Receptors, Estrogen,
pubmed-meshheading:12727922-Transforming Growth Factor beta,
pubmed-meshheading:12727922-Wound Healing
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pubmed:year |
2003
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pubmed:articleTitle |
Estrogen modulates cutaneous wound healing by downregulating macrophage migration inhibitory factor.
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pubmed:affiliation |
School of Biological Sciences, University of Manchester, Manchester, United Kingdom. gillian.s.ashcroft@man.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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