|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2003-5-2
|
|
pubmed:abstractText |
This article presents a meta analysis of data from three cohorts occupationally exposed to TCDD and related compounds. A statistically significant (p = 0.02) trend was found in total cancer mortality with increasing dioxin exposure. The trend tests show an increase in total cancer at cumulative TEQ (unit of measurement for TCDD-like compounds that is defined as the amount of TCDD that would produce the same toxicity as a mixture of TCDD-like compounds) serum levels that would result from lifetime intake of 7 pg TEQ/kg body weight/day, with no increase at 6 pg/kg/day. A linear dose response provided a good fit to the combined data and predicted an ED(01) (dioxin exposure resulting in a 0.01 increase in lifetime risk of cancer mortality) of 45 pg/kg/day (95% confidence interval, 21-324). The U.S. Environmental Protection Agency estimates that current lifetime human exposures to dioxin average approximately 1 pg/kg/day (99% percentile: 3 pg/kg/day). Although it appears unlikely that current exposures through foods would reach either 7 pg/kg/day or the ED(01), our analysis argues for careful consideration of the upper ranges of long-term average exposures for dioxins.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-10328108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-11140441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-11532787,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-11606796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-12948881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-1985242,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-4005384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-7716767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-8207757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-8354568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-8502790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-8882118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-9583720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-9599713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/12727594-9599714
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0091-6765
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
111
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
681-7
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Meta-analysis of dioxin cancer dose response for three occupational cohorts.
|
|
pubmed:affiliation |
Environ International Corporation, Ruston, Louisiana 71270, USA. kcrump@environcorp.com
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Meta-Analysis
|
