Source:http://linkedlifedata.com/resource/pubmed/id/12726861
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2003-5-2
|
| pubmed:abstractText |
Hypoxia unleashes the invasive and metastatic potential of tumor cells by largely unknown mechanisms. The Met tyrosine kinase, a high affinity receptor for hepatocyte growth factor (HGF), plays a crucial role in controlling invasive growth and is often overexpressed in cancer. Here we show that: (1) hypoxia activates transcription of the met protooncogene, resulting in higher levels of Met; (2) hypoxic areas of tumors overexpress Met; (3) hypoxia amplifies HGF signaling; (4) hypoxia synergizes with HGF in inducing invasion; (5) the proinvasive effects of hypoxia are mimicked by Met overexpression; and (6) inhibition of Met expression prevents hypoxia-induced invasive growth. These data show that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
1535-6108
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
3
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
347-61
|
| pubmed:dateRevised |
2009-11-19
|
| pubmed:meshHeading |
pubmed-meshheading:12726861-Anoxia,
pubmed-meshheading:12726861-Base Sequence,
pubmed-meshheading:12726861-Blotting, Northern,
pubmed-meshheading:12726861-Blotting, Western,
pubmed-meshheading:12726861-Cell Movement,
pubmed-meshheading:12726861-Cells, Cultured,
pubmed-meshheading:12726861-Fluorescent Antibody Technique,
pubmed-meshheading:12726861-Gene Transfer Techniques,
pubmed-meshheading:12726861-Hepatocyte Growth Factor,
pubmed-meshheading:12726861-Humans,
pubmed-meshheading:12726861-Molecular Sequence Data,
pubmed-meshheading:12726861-Neoplasm Invasiveness,
pubmed-meshheading:12726861-Promoter Regions, Genetic,
pubmed-meshheading:12726861-Proto-Oncogene Proteins c-met,
pubmed-meshheading:12726861-RNA, Messenger,
pubmed-meshheading:12726861-Transcription, Genetic,
pubmed-meshheading:12726861-Tumor Cells, Cultured
|
| pubmed:year |
2003
|
| pubmed:articleTitle |
Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene.
|
| pubmed:affiliation |
Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|