The Diaphanous-related formins are effectors for Rho GTPases. Two recent reports have unveiled previously unappreciated activities of Drf3 (mDia2), eliciting cytoskeletal rearrangements at the behest of Cdc42, and of DRF2 (hDia2C), regulating endosome dynamics for RhoD.
Abramson Family Cancer Research Institute, BRB II/III, 421 Curie Blvd. University of Pennsylvania, Philadelphia, PA 19104, USA. molson@mail.med.upenn.edu
