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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2003-5-2
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pubmed:abstractText |
In mammals, the master circadian clock that drives many biochemical, physiological, and behavioral rhythms is located in the suprachiasmatic nuclei (SCN) of the hypothalamus. Generation and maintenance of circadian rhythmicity rely on complex interlocked transcriptional/translational feedback loops involving a set of clock genes. Among the molecular components driving the mammalian circadian clock are the Period 1 and 2 (mPer1 and mPer2) genes. Because the periodicity of the clock is not exactly 24 hr, it has to be adjusted periodically. The major stimulus for adjustment (resetting) of the clock is nocturnal light. It evokes activation of signaling pathways in the SCN that ultimately lead to expression of mPer1 and mPer2 genes conveying adjustment of the clock.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP Response...,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Per1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Per2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Period Circadian Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/cGMP-dependent protein kinase II
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-9822
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
725-33
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:12725729-Animals,
pubmed-meshheading:12725729-Cell Cycle Proteins,
pubmed-meshheading:12725729-Circadian Rhythm,
pubmed-meshheading:12725729-Cyclic AMP Response Element-Binding Protein,
pubmed-meshheading:12725729-Cyclic GMP-Dependent Protein Kinases,
pubmed-meshheading:12725729-Electroretinography,
pubmed-meshheading:12725729-Gene Expression Regulation,
pubmed-meshheading:12725729-Immunoblotting,
pubmed-meshheading:12725729-Immunohistochemistry,
pubmed-meshheading:12725729-In Situ Hybridization,
pubmed-meshheading:12725729-Male,
pubmed-meshheading:12725729-Mice,
pubmed-meshheading:12725729-Mice, Knockout,
pubmed-meshheading:12725729-Nuclear Proteins,
pubmed-meshheading:12725729-Period Circadian Proteins,
pubmed-meshheading:12725729-Photic Stimulation,
pubmed-meshheading:12725729-Signal Transduction,
pubmed-meshheading:12725729-Suprachiasmatic Nucleus,
pubmed-meshheading:12725729-Transcription Factors,
pubmed-meshheading:12725729-Transcriptional Activation
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pubmed:year |
2003
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pubmed:articleTitle |
cGMP-dependent protein kinase II modulates mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock.
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pubmed:affiliation |
Department of Medicine, Division of Biochemistry, University of Fribourg, 1700 Fribourg, Switzerland.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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