| pubmed-article:12721307 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C0020364 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C1426796 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C1157248 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C2700640 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:12721307 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:12721307 | pubmed:issue | 28 | lld:pubmed |
| pubmed-article:12721307 | pubmed:dateCreated | 2003-7-4 | lld:pubmed |
| pubmed-article:12721307 | pubmed:abstractText | Coenzyme Q (Q) is a lipid that functions as an electron carrier in the mitochondrial respiratory chain in eukaryotes. There are eight complementation groups of Q-deficient Saccharomyces cerevisiae mutants, designated coq1-coq8. Here we have isolated the COQ6 gene by functional complementation and, in contrast to a previous report, find it is not an essential gene. coq6 mutants are unable to grow on nonfermentable carbon sources and do not synthesize Q but instead accumulate the Q biosynthetic intermediate 3-hexaprenyl-4-hydroxybenzoic acid. The Coq6 polypeptide is imported into the mitochondria in a membrane potential-dependent manner. Coq6p is a peripheral membrane protein that localizes to the matrix side of the inner mitochondrial membrane. Based on sequence homology to known proteins, we suggest that COQ6 encodes a flavin-dependent monooxygenase required for one or more steps in Q biosynthesis. | lld:pubmed |
| pubmed-article:12721307 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12721307 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12721307 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12721307 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:12721307 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:12721307 | pubmed:author | pubmed-author:ClarkeCatheri... | lld:pubmed |
| pubmed-article:12721307 | pubmed:author | pubmed-author:TzagoloffAlex... | lld:pubmed |
| pubmed-article:12721307 | pubmed:author | pubmed-author:LeePeter TPT | lld:pubmed |
| pubmed-article:12721307 | pubmed:author | pubmed-author:JonassenTanya... | lld:pubmed |
| pubmed-article:12721307 | pubmed:author | pubmed-author:RothmanSteven... | lld:pubmed |
| pubmed-article:12721307 | pubmed:author | pubmed-author:GinPeterP | lld:pubmed |
| pubmed-article:12721307 | pubmed:author | pubmed-author:HsuAdam YAY | lld:pubmed |
| pubmed-article:12721307 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12721307 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:12721307 | pubmed:volume | 278 | lld:pubmed |
| pubmed-article:12721307 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12721307 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12721307 | pubmed:pagination | 25308-16 | lld:pubmed |
| pubmed-article:12721307 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12721307 | pubmed:meshHeading | pubmed-meshheading:12721307... | lld:pubmed |
| pubmed-article:12721307 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12721307 | pubmed:articleTitle | The Saccharomyces cerevisiae COQ6 gene encodes a mitochondrial flavin-dependent monooxygenase required for coenzyme Q biosynthesis. | lld:pubmed |
| pubmed-article:12721307 | pubmed:affiliation | Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California 90095, USA. | lld:pubmed |
| pubmed-article:12721307 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12721307 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| entrez-gene:853170 | entrezgene:pubmed | pubmed-article:12721307 | lld:entrezgene |
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