|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0009402,
umls-concept:C0016360,
umls-concept:C0017262,
umls-concept:C0029298,
umls-concept:C0036667,
umls-concept:C0040085,
umls-concept:C0058126,
umls-concept:C0185117,
umls-concept:C0312418,
umls-concept:C0439849,
umls-concept:C0812425,
umls-concept:C2911684
|
|
pubmed:issue |
2
|
|
pubmed:dateCreated |
2003-4-29
|
|
pubmed:abstractText |
The site of action of the 5-fluorouracil (5-FU) antitumor effect has been explicated in recent years. Many studies have investigated enzymes involved in 5-FU metabolism in attempts to predict this effect, and a correlation of enzyme activity with the 5-FU drug sensitivity test has been reported. The aim of this study was to identify the biochemical response determinants of 5-FU. Additionally, we aimed to clarify the association between cell proliferative activity and the response to 5-FU of colorectal cancer.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1341-9625
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
72-8
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:12720098-Adenocarcinoma,
pubmed-meshheading:12720098-Adult,
pubmed-meshheading:12720098-Aged,
pubmed-meshheading:12720098-Aged, 80 and over,
pubmed-meshheading:12720098-Biopsy, Needle,
pubmed-meshheading:12720098-Cell Division,
pubmed-meshheading:12720098-Colorectal Neoplasms,
pubmed-meshheading:12720098-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:12720098-Drug Resistance, Neoplasm,
pubmed-meshheading:12720098-Female,
pubmed-meshheading:12720098-Fluorouracil,
pubmed-meshheading:12720098-Humans,
pubmed-meshheading:12720098-Immunohistochemistry,
pubmed-meshheading:12720098-Male,
pubmed-meshheading:12720098-Middle Aged,
pubmed-meshheading:12720098-Neoplasm Staging,
pubmed-meshheading:12720098-Orotate Phosphoribosyltransferase,
pubmed-meshheading:12720098-Oxidoreductases,
pubmed-meshheading:12720098-Probability,
pubmed-meshheading:12720098-Prospective Studies,
pubmed-meshheading:12720098-Sampling Studies,
pubmed-meshheading:12720098-Sensitivity and Specificity,
pubmed-meshheading:12720098-Statistics, Nonparametric,
pubmed-meshheading:12720098-Thymidylate Synthase,
pubmed-meshheading:12720098-Tumor Cells, Cultured,
pubmed-meshheading:12720098-Tumor Markers, Biological
|
|
pubmed:year |
2003
|
|
pubmed:articleTitle |
Relationships between the expression of thymidylate synthase, dihydropyrimidine dehydrogenase, and orotate phosphoribosyltransferase and cell proliferative activity and 5-fluorouracil sensitivity in colorectal carcinoma.
|
|
pubmed:affiliation |
Tokyo Women's Medical University, Second Department of Surgery, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study
|
