| pubmed-article:12719551 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0008356 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0123759 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0442118 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0017968 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0042196 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C0205373 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C1522673 | lld:lifeskim |
| pubmed-article:12719551 | lifeskim:mentions | umls-concept:C1711351 | lld:lifeskim |
| pubmed-article:12719551 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:12719551 | pubmed:dateCreated | 2003-4-29 | lld:pubmed |
| pubmed-article:12719551 | pubmed:abstractText | We have investigated the induction of protective mucosal immunity to human immunodeficiency virus type 1 (HIV-1) isolate 89.6 by intranasal (i.n.) immunization of mice with gp120 and gp140 together with interleukin-12 (IL-12) and cholera toxin subunit B (CTB) as adjuvants. It was found that both IL-12 and CTB were required to elicit mucosal antibody responses and that i.n. immunization resulted in increased total, immunoglobulin G1 (IgG1), and IgG2a anti-HIV-1 antibody levels in serum; increased total, IgG1, IgG2a, and IgA antibody expression in bronchoalveolar lavage fluids; and increased IgA antibody levels in vaginal washes. Levels of anti-HIV-1 antibodies in both sera and secretions were higher in groups immunized with gp140 than in those immunized with gp120. However, only gp120-specific mucosal antibodies demonstrated neutralizing activity against HIV-1 89.6. Taken together, the results show that IL-12 and CTB act synergistically to enhance both systemic and local mucosal antibody responses to HIV-1 glycoproteins and that even though gp140 induces higher antibody titers than gp120, only gp120-specific mucosal antibodies interfere with virus infectivity. | lld:pubmed |
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| pubmed-article:12719551 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12719551 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12719551 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12719551 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12719551 | pubmed:month | May | lld:pubmed |
| pubmed-article:12719551 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:12719551 | pubmed:author | pubmed-author:MetzgerDennis... | lld:pubmed |
| pubmed-article:12719551 | pubmed:author | pubmed-author:BroderChristo... | lld:pubmed |
| pubmed-article:12719551 | pubmed:author | pubmed-author:AlbuDiana IDI | lld:pubmed |
| pubmed-article:12719551 | pubmed:author | pubmed-author:Jones-TrowerA... | lld:pubmed |
| pubmed-article:12719551 | pubmed:author | pubmed-author:WoronAmy MAM | lld:pubmed |
| pubmed-article:12719551 | pubmed:author | pubmed-author:StellrechtKat... | lld:pubmed |
| pubmed-article:12719551 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12719551 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:12719551 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12719551 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12719551 | pubmed:pagination | 5589-97 | lld:pubmed |
| pubmed-article:12719551 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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