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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2003-5-20
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pubmed:abstractText |
Decreased heart rate variability (HRV) and increased blood pressure variability (BPV), determined in part by nitric oxide (NO)-dependent endothelial dysfunction, are correlated with adverse prognosis in cardiovascular diseases. We examined potential alterations in BPV and HRV in genetically dyslipidemic, apolipoprotein (apo) E-/-, and control mice and the effect of chronic statin treatment on these parameters in relation to their NO synthase (NOS)-modifying properties.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Cav1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolin 1,
http://linkedlifedata.com/resource/pubmed/chemical/Caveolins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrimidines,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/rosuvastatin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
20
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2480-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:12719275-Animals,
pubmed-meshheading:12719275-Aorta,
pubmed-meshheading:12719275-Apolipoproteins E,
pubmed-meshheading:12719275-Autonomic Nervous System,
pubmed-meshheading:12719275-Blood Pressure,
pubmed-meshheading:12719275-Blood Pressure Monitoring, Ambulatory,
pubmed-meshheading:12719275-Caveolin 1,
pubmed-meshheading:12719275-Caveolins,
pubmed-meshheading:12719275-Cholesterol,
pubmed-meshheading:12719275-Chronobiology Disorders,
pubmed-meshheading:12719275-Electrocardiography, Ambulatory,
pubmed-meshheading:12719275-Fluorobenzenes,
pubmed-meshheading:12719275-Heart Rate,
pubmed-meshheading:12719275-Hyperlipidemias,
pubmed-meshheading:12719275-Mice,
pubmed-meshheading:12719275-Mice, Inbred C57BL,
pubmed-meshheading:12719275-Mice, Knockout,
pubmed-meshheading:12719275-Myocardium,
pubmed-meshheading:12719275-Nitric Oxide,
pubmed-meshheading:12719275-Nitric Oxide Synthase,
pubmed-meshheading:12719275-Nitric Oxide Synthase Type II,
pubmed-meshheading:12719275-Nitric Oxide Synthase Type III,
pubmed-meshheading:12719275-Pyrimidines,
pubmed-meshheading:12719275-Sulfonamides,
pubmed-meshheading:12719275-Treatment Outcome
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pubmed:year |
2003
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pubmed:articleTitle |
Rosuvastatin decreases caveolin-1 and improves nitric oxide-dependent heart rate and blood pressure variability in apolipoprotein E-/- mice in vivo.
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pubmed:affiliation |
Department of Medicine, Unit of Pharmacology and Therapeutics, University of Louvain, School of Medicine, Ave Mounier 53, 1200 Brussels, Belgium.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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