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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2003-4-29
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pubmed:abstractText |
Brain dopaminergic transmission is a critical component in numerous vital functions, and its dysfunction is involved in several disorders, including addiction and Parkinson's disease. Responses to dopamine are mediated via G protein-coupled dopamine receptors (D1-D5). Desensitization of G protein-coupled receptors is mediated via phosphorylation by members of the family of G protein-coupled receptor kinases (GRK1-GRK7). Here we show that GRK6-deficient mice are supersensitive to the locomotor-stimulating effect of psychostimulants, including cocaine and amphetamine. In addition, these mice demonstrate an enhanced coupling of striatal D2-like dopamine receptors to G proteins and augmented locomotor response to direct dopamine agonists both in intact and in dopamine-depleted animals. The present study indicates that postsynaptic D2-like dopamine receptors are physiological targets for GRK6 and suggests that this regulatory mechanism contributes to central dopaminergic supersensitivity.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amphetamine,
http://linkedlifedata.com/resource/pubmed/chemical/Central Nervous System Stimulants,
http://linkedlifedata.com/resource/pubmed/chemical/Cocaine,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine and cAMP-Regulated...,
http://linkedlifedata.com/resource/pubmed/chemical/G-Protein-Coupled Receptor Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/G-protein-coupled receptor kinase 6,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phenethylamines,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Serine-Threonine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D1,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2,
http://linkedlifedata.com/resource/pubmed/chemical/phenethylamine
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0896-6273
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pubmed:author |
pubmed-author:BohnLaura MLM,
pubmed-author:CaronMarc GMG,
pubmed-author:CyrMichelM,
pubmed-author:GainetdinovRaul RRR,
pubmed-author:KimKyeong ManKM,
pubmed-author:LaaksoAkiA,
pubmed-author:LefkowitzRobert JRJ,
pubmed-author:MacraeAlexander DAD,
pubmed-author:PremontRichard TRT,
pubmed-author:SotnikovaTatyana DTD,
pubmed-author:TorresGonzalo EGE
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-303
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:12718862-Amphetamine,
pubmed-meshheading:12718862-Animals,
pubmed-meshheading:12718862-Behavior, Animal,
pubmed-meshheading:12718862-Binding, Competitive,
pubmed-meshheading:12718862-Central Nervous System Stimulants,
pubmed-meshheading:12718862-Cocaine,
pubmed-meshheading:12718862-Corpus Striatum,
pubmed-meshheading:12718862-Dopamine,
pubmed-meshheading:12718862-Dopamine Agonists,
pubmed-meshheading:12718862-Dopamine and cAMP-Regulated Phosphoprotein 32,
pubmed-meshheading:12718862-Dose-Response Relationship, Drug,
pubmed-meshheading:12718862-G-Protein-Coupled Receptor Kinases,
pubmed-meshheading:12718862-Gene Targeting,
pubmed-meshheading:12718862-Mice,
pubmed-meshheading:12718862-Mice, Knockout,
pubmed-meshheading:12718862-Mice, Mutant Strains,
pubmed-meshheading:12718862-Motor Activity,
pubmed-meshheading:12718862-Nerve Tissue Proteins,
pubmed-meshheading:12718862-Neurons,
pubmed-meshheading:12718862-Phenethylamines,
pubmed-meshheading:12718862-Phosphoproteins,
pubmed-meshheading:12718862-Protein-Serine-Threonine Kinases,
pubmed-meshheading:12718862-Receptors, Dopamine D1,
pubmed-meshheading:12718862-Receptors, Dopamine D2
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pubmed:year |
2003
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pubmed:articleTitle |
Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice.
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pubmed:affiliation |
Howard Hughes Medical Institute Laboratories, Duke University Medical Center, Durham, NC 27710, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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