Linked Life Data

12718728

Source:http://linkedlifedata.com/resource/pubmed/id/12718728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2003-4-29
pubmed:abstractText
Chemokines play a central role in regulating leukocyte migration. The recently discovered CC chemokine ligand 27 (CCL27), through interaction with its cognate receptor, CC chemokine receptor 10 (CCR10), appears to be involved in attracting a subset of memory T cells to the skin during some cutaneous inflammatory responses. Strangely, CCL27 can also be produced as a non-secreted form, as a result of alternative splicing. This protein, termed PESKY, is targeted to the nucleus where it is able to modulate transcription and alter cell morphology. Specifically, PESKY induces a rearrangement of the actin cytoskeleton, manifest by the disruption of stress fibres. This consequently enhances cell motility. Surprisingly, secreted CCL27 can also reach the nucleus after CCR10-mediated internalisation, where it may also be capable of directly modulating transcription to alter cell behaviour. This review will discuss these unprecedented findings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
1471-2598
pubmed:author
pubmed:issnType
Print
pubmed:volume
3
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15-22
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
CCL27/PESKY: a novel paradigm for chemokine function.
pubmed:affiliation
The Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Bearsden, Glasgow, G61 1BD, UK. r.nibbs@beatson.gla.ac.uk
pubmed:publicationType
Journal Article, Review