Source:http://linkedlifedata.com/resource/pubmed/id/12717621
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2003-4-28
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pubmed:abstractText |
To examine the relationship of human leukocyte antigen (HLA) class I and transporter associated with antigen processing (TAP) genes with resistance to human immunodeficiency virus type 1 (HIV-1) infection, 100 HIV-seronegative men who had been exposed repeatedly to HIV-1 were compared with 184 men who had seroconverted to HIV positive and had lower risk. In the univariate analysis, the HLA-A2 supertype, excluding A*0201 (HLA-A2/6802 supertype; odds ratio [OR], 4.45; 95% confidence interval [CI], 1.33-4.84; P=.009) was associated with resistance to HIV-1 infection; the effect was the result of the presence of the A*0205 subgroup alleles. Susceptibility was associated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08-0.99; P=.037), which suggests that differential preferences for amino acids at the C terminus may influence peptide-binding capacity. TAP2 Ala665 was also associated with resistance (OR, 2.26; 95% CI, 1.35-3.79; P=.002), perhaps because of its higher efficiency in transporting peptides, thus eliciting a greater CD8(+) T cell response, or because of linkage disequilibrium. In multivariate logistic analysis, only the A*0205 subgroup (OR, 5.56; 95% CI, 1.34-23.10; P=.018) and the TAP2 Ala665 (OR, 2.22; 95% CI, 1.28-3.84; P=.005) were associated with resistance.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1899
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pubmed:author |
pubmed-author:CarringtonMaryM,
pubmed-author:DetelsRogerR,
pubmed-author:GaoXiaojiangX,
pubmed-author:JacobsonLisa PLP,
pubmed-author:KaslowRichard ARA,
pubmed-author:LiuChenglongC,
pubmed-author:MargolickJoseph BJB,
pubmed-author:O'BrienStephen JSJ,
pubmed-author:PhairJohnJ,
pubmed-author:RinaldoCharles RCR
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
187
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1404-10
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:12717621-ATP-Binding Cassette Transporters,
pubmed-meshheading:12717621-Adult,
pubmed-meshheading:12717621-Cohort Studies,
pubmed-meshheading:12717621-Genetic Predisposition to Disease,
pubmed-meshheading:12717621-Genotype,
pubmed-meshheading:12717621-HIV Infections,
pubmed-meshheading:12717621-HIV Seropositivity,
pubmed-meshheading:12717621-Histocompatibility Antigens Class I,
pubmed-meshheading:12717621-Humans,
pubmed-meshheading:12717621-Male,
pubmed-meshheading:12717621-Multivariate Analysis,
pubmed-meshheading:12717621-Polymorphism, Genetic
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pubmed:year |
2003
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pubmed:articleTitle |
Association of polymorphisms in human leukocyte antigen class I and transporter associated with antigen processing genes with resistance to human immunodeficiency virus type 1 infection.
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pubmed:affiliation |
School of Public Health, University of California, Los Angeles, CA 90095, USA.
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pubmed:publicationType |
Journal Article,
Multicenter Study
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