| pubmed-article:12717379 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:12717379 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:12717379 | lifeskim:mentions | umls-concept:C0596508 | lld:lifeskim |
| pubmed-article:12717379 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:12717379 | lifeskim:mentions | umls-concept:C0277784 | lld:lifeskim |
| pubmed-article:12717379 | lifeskim:mentions | umls-concept:C0302350 | lld:lifeskim |
| pubmed-article:12717379 | lifeskim:mentions | umls-concept:C0185125 | lld:lifeskim |
| pubmed-article:12717379 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:12717379 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:12717379 | pubmed:dateCreated | 2003-4-28 | lld:pubmed |
| pubmed-article:12717379 | pubmed:abstractText | Embryonic stem (ES) cells provide a unique source for tissue regeneration. We examined whether mouse ES cells can efficiently differentiate into transplantable hepatocytes. ES cells were implanted into mouse livers 24 hours after carbon tetrachloride intoxication; ES-derived cells with several hepatocyte-cell-markers were generated. They were able to grow in vitro and showed morphology consistent with typical mature hepatocytes and expressed hepatocyte-specific genes. After transplantation into the carbon tetrachloride-injured mouse liver, ES-derived green fluorescent protein-positive cells were incorporated into liver tissue and rescued mice from hepatic injury. No teratoma formation was observed in the transplant recipients. In conclusion, ES cells can provide a valuable tool for studying the molecular basis for differentiation of hepatocytes and form the basis for cell therapies. | lld:pubmed |
| pubmed-article:12717379 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12717379 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717379 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:12717379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:12717379 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12717379 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12717379 | pubmed:month | May | lld:pubmed |
| pubmed-article:12717379 | pubmed:issn | 0270-9139 | lld:pubmed |
| pubmed-article:12717379 | pubmed:author | pubmed-author:TerataniTakum... | lld:pubmed |
| pubmed-article:12717379 | pubmed:author | pubmed-author:TeradaMasaaki... | lld:pubmed |
| pubmed-article:12717379 | pubmed:author | pubmed-author:YamamotoHanak... | lld:pubmed |
| pubmed-article:12717379 | pubmed:author | pubmed-author:OchiyaTakahir... | lld:pubmed |
| pubmed-article:12717379 | pubmed:author | pubmed-author:YamanokuchiHi... | lld:pubmed |
| pubmed-article:12717379 | pubmed:author | pubmed-author:AsariAkiraA | lld:pubmed |
| pubmed-article:12717379 | pubmed:author | pubmed-author:QuinnGaryG | lld:pubmed |
| pubmed-article:12717379 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:12717379 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:12717379 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12717379 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12717379 | pubmed:pagination | 983-93 | lld:pubmed |
| pubmed-article:12717379 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:12717379 | pubmed:meshHeading | pubmed-meshheading:12717379... | lld:pubmed |
| pubmed-article:12717379 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12717379 | pubmed:articleTitle | Differentiation of embryonic stem cells into hepatocytes: biological functions and therapeutic application. | lld:pubmed |
| pubmed-article:12717379 | pubmed:affiliation | National Cancer Center Research Institute, Tokyo, Japan. | lld:pubmed |
| pubmed-article:12717379 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12717379 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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