Linked Life Data

12717343

Source:http://linkedlifedata.com/resource/pubmed/id/12717343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2003-4-28
pubmed:abstractText
In the anterior pituitary gland, five distinct hormone producing cell types are generated from common epithelial progenitor cells. This process of cellular determination is controlled by signaling molecules acting on transcription factors, which in turn regulate genes critical for the appearance of hormone producing cells. Two pituitary specific transcription factors, Pit-1 and Prop-1, which are required for generation of hormone producing cells in the anterior pituitary gland, have proved to be important in the cause of hypopituitarism in humans. Mutations in the human PIT-1 gene lead to a combined pituitary hormone deficiency characterized by lack of GH, PRL and TSH. Mutations in the PROP-1 gene, which are a more common cause of hypopituitarism, lead to a clinical phenotype characterized by GH, PRL, TSH, LH and FSH deficiency, and sometimes ACTH deficiency as well.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0391-1977
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
123-33
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency.
pubmed:affiliation
Department of Medicine, Division of Endocrinology, University of California, Irvine, CA 92697-4075, USA.
pubmed:publicationType
Journal Article, Review