Linked Life Data

12717095

Source:http://linkedlifedata.com/resource/pubmed/id/12717095

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-4-28
pubmed:abstractText
Anti-arrhythmic compounds with multiple actions reduce arrhythmic death risk in post-myocardial infarction (MI) patients. Sudden death prevention, however, may rely more on implantable defibrillators than anti-arrhythmic drugs due to ineffective pharmacologic intervention. Widespread use of implantable defibrillators should not obscure the need for development of new anti-arrhythmic drugs. This study tested the hypothesis that combined blockade of I(Na) and I(Ca(L)) prevents ischemia-dependent ventricular fibrillation (VF) in conscious dogs after MI. I(Na) and I(Ca(L)) blockade was accomplished with levosemotiadil in 11 dogs known to be at high risk for VF during 2 min of coronary occlusion during submaximal treadmill exercise 30 days after MI. Negative chronotropic effect of levosemotiadil was examined using the heart rate response to isoproterenol and comparing it with response to propranolol. Levosemotiadil prevented VF in 64% (7 of 11) of the high-risk animals. Heart rate responses to myocardial ischemia and to graded doses of isoproterenol were blunted by the high dose of levosemotiadil. Propranolol prevented VF in 73% (8 of 11) of the dogs. Levosemotiadil had approximately one half the beta-blocking activity of propranolol. The combination of I(Na) and I(Ca(L)) channel blockade coupled with partial beta-adrenergic blockade was equally effective in preventing VF as propranolol.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
665-70
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:12717095-Adrenergic beta-Antagonists, pubmed-meshheading:12717095-Animals, pubmed-meshheading:12717095-Anti-Arrhythmia Agents, pubmed-meshheading:12717095-Calcium Channel Blockers, pubmed-meshheading:12717095-Death, Sudden, Cardiac, pubmed-meshheading:12717095-Depression, Chemical, pubmed-meshheading:12717095-Dogs, pubmed-meshheading:12717095-Drug Synergism, pubmed-meshheading:12717095-Drug Therapy, Combination, pubmed-meshheading:12717095-Heart Rate, pubmed-meshheading:12717095-Isoproterenol, pubmed-meshheading:12717095-Myocardial Infarction, pubmed-meshheading:12717095-Physical Conditioning, Animal, pubmed-meshheading:12717095-Propranolol, pubmed-meshheading:12717095-Sodium Channel Blockers, pubmed-meshheading:12717095-Thiazoles, pubmed-meshheading:12717095-Ventricular Fibrillation
pubmed:year
2003
pubmed:articleTitle
Combined sodium and calcium channel blockade in prevention of lethal arrhythmias.
pubmed:affiliation
Department of Physiology, Cardiovascular Diseases Section, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA. philip-adamson@ouhsc.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't