| pubmed-article:12716949 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C0031689 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C0234404 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C1533157 | lld:lifeskim |
| pubmed-article:12716949 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:12716949 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:12716949 | pubmed:dateCreated | 2003-4-28 | lld:pubmed |
| pubmed-article:12716949 | pubmed:abstractText | Studies of memory consolidation have identified multiple phases or stages in the formation of memories. The multiple components of memory can be broadly divided into the three phases; short-term, intermediate-term, and long-term. Although molecular changes underlying short- and long-term memory have been examined extensively, the molecular mechanisms supporting the formation of intermediate-term memory are poorly understood. In several examples of cellular and synaptic plasticity, intermediate memory depends on translation but not transcription. One-trial conditioning in Hermissenda results in the development of intermediate memory that is associated with enhanced cellular excitability and the phosphorylation of a 24 kDa protein referred to as conditioned stimulus pathway phosphoprotein (Csp24). Using amino acid sequences derived from Csp24 peptide fragments, a full-length cDNA was cloned and shown to contain multiple beta-thymosin-like domains. The expression of Csp24 and the development of enhanced excitability, a characteristic of intermediate memory, were blocked by antisense oligonucleotide-mediated downregulation of Csp24 without affecting the induction of immediate enhanced excitability, a characteristic of short-term memory. These results demonstrate that the synthesis of Csp24 is required for the development and maintenance of intermediate memory. | lld:pubmed |
| pubmed-article:12716949 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12716949 | pubmed:language | eng | lld:pubmed |
| pubmed-article:12716949 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:12716949 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:12716949 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:12716949 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:12716949 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:12716949 | pubmed:author | pubmed-author:CrowTerryT | lld:pubmed |
| pubmed-article:12716949 | pubmed:author | pubmed-author:TianLian-Ming... | lld:pubmed |
| pubmed-article:12716949 | pubmed:author | pubmed-author:DashPramod... | lld:pubmed |
| pubmed-article:12716949 | pubmed:author | pubmed-author:RedellJohn... | lld:pubmed |
| pubmed-article:12716949 | pubmed:author | pubmed-author:Xue-BianJuanJ | lld:pubmed |
| pubmed-article:12716949 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:12716949 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:12716949 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:12716949 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:12716949 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:12716949 | pubmed:pagination | 3415-22 | lld:pubmed |
| pubmed-article:12716949 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:12716949 | pubmed:year | 2003 | lld:pubmed |
| pubmed-article:12716949 | pubmed:articleTitle | Inhibition of conditioned stimulus pathway phosphoprotein 24 expression blocks the development of intermediate-term memory in Hermissenda. | lld:pubmed |
| pubmed-article:12716949 | pubmed:affiliation | Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA. terry.crow@uth.tmc.edu | lld:pubmed |
| pubmed-article:12716949 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:12716949 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:12716949 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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