Source:http://linkedlifedata.com/resource/pubmed/id/12716949
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
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| pubmed:dateCreated |
2003-4-28
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| pubmed:abstractText |
Studies of memory consolidation have identified multiple phases or stages in the formation of memories. The multiple components of memory can be broadly divided into the three phases; short-term, intermediate-term, and long-term. Although molecular changes underlying short- and long-term memory have been examined extensively, the molecular mechanisms supporting the formation of intermediate-term memory are poorly understood. In several examples of cellular and synaptic plasticity, intermediate memory depends on translation but not transcription. One-trial conditioning in Hermissenda results in the development of intermediate memory that is associated with enhanced cellular excitability and the phosphorylation of a 24 kDa protein referred to as conditioned stimulus pathway phosphoprotein (Csp24). Using amino acid sequences derived from Csp24 peptide fragments, a full-length cDNA was cloned and shown to contain multiple beta-thymosin-like domains. The expression of Csp24 and the development of enhanced excitability, a characteristic of intermediate memory, were blocked by antisense oligonucleotide-mediated downregulation of Csp24 without affecting the induction of immediate enhanced excitability, a characteristic of short-term memory. These results demonstrate that the synthesis of Csp24 is required for the development and maintenance of intermediate memory.
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| pubmed:grant | |
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Microfilament Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Oligonucleotides, Antisense,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Thymosin
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1529-2401
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:day |
15
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| pubmed:volume |
23
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3415-22
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| pubmed:dateRevised |
2007-11-14
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| pubmed:meshHeading |
pubmed-meshheading:12716949-Action Potentials,
pubmed-meshheading:12716949-Alternative Splicing,
pubmed-meshheading:12716949-Amino Acid Sequence,
pubmed-meshheading:12716949-Animals,
pubmed-meshheading:12716949-Cloning, Molecular,
pubmed-meshheading:12716949-Cluster Analysis,
pubmed-meshheading:12716949-Conditioning, Classical,
pubmed-meshheading:12716949-Cytoskeleton,
pubmed-meshheading:12716949-DNA, Complementary,
pubmed-meshheading:12716949-Memory,
pubmed-meshheading:12716949-Microfilament Proteins,
pubmed-meshheading:12716949-Molecular Sequence Data,
pubmed-meshheading:12716949-Mollusca,
pubmed-meshheading:12716949-Nervous System,
pubmed-meshheading:12716949-Neuronal Plasticity,
pubmed-meshheading:12716949-Oligonucleotides, Antisense,
pubmed-meshheading:12716949-Phosphoproteins,
pubmed-meshheading:12716949-Phosphorylation,
pubmed-meshheading:12716949-Phylogeny,
pubmed-meshheading:12716949-RNA, Messenger,
pubmed-meshheading:12716949-Sequence Homology, Amino Acid,
pubmed-meshheading:12716949-Signal Transduction,
pubmed-meshheading:12716949-Thymosin
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| pubmed:year |
2003
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| pubmed:articleTitle |
Inhibition of conditioned stimulus pathway phosphoprotein 24 expression blocks the development of intermediate-term memory in Hermissenda.
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| pubmed:affiliation |
Department of Neurobiology and Anatomy, University of Texas Medical School, Houston, Texas 77225, USA. terry.crow@uth.tmc.edu
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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