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rdf:type |
|
|
lifeskim:mentions |
|
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pubmed:issue |
5
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|
pubmed:dateCreated |
2003-4-28
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|
pubmed:abstractText |
Interleukin-6 (IL-6) is a multifunctional cytokine that mediates inflammatory tissue destruction. A G to C substitution at position -174 in the promoter of IL-6 gene reduces in vitro transcription of IL-6. This polymorphism has been associated with inflammatory diseases like chronic arthritis.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
D
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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pubmed:month |
May
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|
pubmed:issn |
0303-6979
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
438-42
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12716337-Adult,
pubmed-meshheading:12716337-Alleles,
pubmed-meshheading:12716337-Base Sequence,
pubmed-meshheading:12716337-Brazil,
pubmed-meshheading:12716337-Chi-Square Distribution,
pubmed-meshheading:12716337-Chronic Disease,
pubmed-meshheading:12716337-Cytosine,
pubmed-meshheading:12716337-European Continental Ancestry Group,
pubmed-meshheading:12716337-Female,
pubmed-meshheading:12716337-Gene Frequency,
pubmed-meshheading:12716337-Genetic Predisposition to Disease,
pubmed-meshheading:12716337-Genotype,
pubmed-meshheading:12716337-Guanine,
pubmed-meshheading:12716337-Humans,
pubmed-meshheading:12716337-Inflammation Mediators,
pubmed-meshheading:12716337-Interleukin-6,
pubmed-meshheading:12716337-Male,
pubmed-meshheading:12716337-Periodontitis,
pubmed-meshheading:12716337-Polymorphism, Genetic,
pubmed-meshheading:12716337-Promoter Regions, Genetic,
pubmed-meshheading:12716337-Transcription, Genetic
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pubmed:year |
2003
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|
pubmed:articleTitle |
Polymorphism at position -174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population.
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pubmed:affiliation |
Department of Morphology, Dental School of Piracicaba, State University of Campinas, SP, Brazil.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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