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rdf:type |
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lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0038435,
umls-concept:C0086418,
umls-concept:C1314939,
umls-concept:C1412622,
umls-concept:C1415761,
umls-concept:C1421527,
umls-concept:C1512409,
umls-concept:C1704259,
umls-concept:C1705987,
umls-concept:C1708295,
umls-concept:C1879547,
umls-concept:C2239176
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pubmed:issue |
5
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pubmed:dateCreated |
2003-4-25
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pubmed:abstractText |
We identified the glucose-regulated protein (grp) 78 as a transformation-associated gene in hepatocellular carcinoma (HCC). Grp78 is a molecular chaperone involved in the unfolded protein response, the expression of which can be regulated by the transcription factors ATF6 and XBP1. Thus, we investigated the regulatory mechanisms of the grp78 gene in liver malignancy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/ATF6 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Activating Transcription Factor 6,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Heat-Shock Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Molecular Chaperones,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/molecular chaperone GRP78,
http://linkedlifedata.com/resource/pubmed/chemical/regulatory factor X transcription...
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0168-8278
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pubmed:author |
pubmed-author:AraiMasaakiM,
pubmed-author:HadaAkiyukiA,
pubmed-author:ImazekiNobuoN,
pubmed-author:KondohNobuoN,
pubmed-author:MatsubaraOsamuO,
pubmed-author:MoriKazutoshiK,
pubmed-author:OkadaTetsuyaT,
pubmed-author:ShudaMasahiroM,
pubmed-author:TanakaKenjiK,
pubmed-author:WakatsukiToruT,
pubmed-author:YamamotoMikioM,
pubmed-author:YamamotoNaokiN
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
605-14
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:12713871-Activating Transcription Factor 6,
pubmed-meshheading:12713871-Adult,
pubmed-meshheading:12713871-Aged,
pubmed-meshheading:12713871-Carcinoma, Hepatocellular,
pubmed-meshheading:12713871-Carrier Proteins,
pubmed-meshheading:12713871-Cell Line, Tumor,
pubmed-meshheading:12713871-DNA-Binding Proteins,
pubmed-meshheading:12713871-Endoplasmic Reticulum,
pubmed-meshheading:12713871-Female,
pubmed-meshheading:12713871-Gene Expression Profiling,
pubmed-meshheading:12713871-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:12713871-Heat-Shock Proteins,
pubmed-meshheading:12713871-Humans,
pubmed-meshheading:12713871-Immunoblotting,
pubmed-meshheading:12713871-Immunohistochemistry,
pubmed-meshheading:12713871-Liver Neoplasms,
pubmed-meshheading:12713871-Male,
pubmed-meshheading:12713871-Middle Aged,
pubmed-meshheading:12713871-Molecular Chaperones,
pubmed-meshheading:12713871-Promoter Regions, Genetic,
pubmed-meshheading:12713871-RNA, Messenger,
pubmed-meshheading:12713871-RNA Splicing,
pubmed-meshheading:12713871-Stress, Physiological,
pubmed-meshheading:12713871-Transcription Factors
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pubmed:year |
2003
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pubmed:articleTitle |
Activation of the ATF6, XBP1 and grp78 genes in human hepatocellular carcinoma: a possible involvement of the ER stress pathway in hepatocarcinogenesis.
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pubmed:affiliation |
Department of Microbiology and Cell Biology, The Tokyo Metropolitan Institute of Medical Science, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo 113-8613, Japan.
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pubmed:publicationType |
Journal Article
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