Linked Life Data

12713651

Source:http://linkedlifedata.com/resource/pubmed/id/12713651

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2003-4-25
pubmed:abstractText
The conditioned place preference (CPP) task has been used extensively to investigate the neurobiological bases of drug-induced reward. The initial expression of a CPP involves memory for an association between environmental stimuli and the affective state produced by a rewarding treatment. The present experiments examined the hypothesis that post-trial administration of glucose can facilitate memory consolidation processes underlying the extinction of drug-induced CPP behaviour. Adult male Long-Evans rats acquired an amphetamine CPP, and subsequently received extinction training. Immediately following extinction training, separate groups of rats received peripheral (100 mg/kg, 500 mg/kg, or 2 g/kg) or intra-amygdala (basolateral nucleus; 1.5 micro g/0.5 micro L or 10 micro g/0.5 micro L) injections of glucose or vehicle. Peripheral (100 mg/kg and 2 g/kg) and intra-amygdala (1.5 and 10 micro g) glucose injections facilitated the extinction of amphetamine CPP behaviour relative to vehicle-injected controls. Postextinction trial peripheral or intra amygdala glucose injections that were delayed 2 h had no effect. The findings indicate that: (i) extinction of approach behaviour to drug-associated cues involves the formation of new memories that undergo a time-dependent consolidation process; and (ii), systemic or intra-amygdala administration of a known memory-enhancing agent facilitates extinction of drug-induced CPP behaviour.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1482-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2003
pubmed:articleTitle
Systemic or intra-amygdala injections of glucose facilitate memory consolidation for extinction of drug-induced conditioned reward.
pubmed:affiliation
Department of Psychology, Yale University, 2 Hillhouse Ave, New Haven CT 06520, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.