Linked Life Data

12713592

Source:http://linkedlifedata.com/resource/pubmed/id/12713592

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2003-4-25
pubmed:abstractText
In this paper, the cDNA microarray technique was used to investigate the gene expression profiles of human fibroblasts irradiated by low-intensity red light. Proliferation assays showed that the fibroblast HS27 cells responded with a curve effect to different doses of low-intensity red light irradiation at a wavelength of 628 nm. An optimal dose of 0.88 J per cm2 was chosen for subsequent cDNA microarray experiments. The gene expression profiles revealed that 111 genes were regulated by the red light irradiation and can be grouped into 10 functional categories. Most of these genes directly or indirectly play roles in the enhancement of cell proliferation and the suppression of apoptosis. Two signaling pathways, the p38 mitogen-activated protein kinase signaling pathway and the platelet-derived growth factor signaling pathway, were found to be involved in cell growth induced by irradiation of low-intensity red light. Several genes related to antioxidation and mitochondria energy metabolism were also found to express differentially upon irradiation. This study provides insight into the molecular mechanisms associated with the beneficial effects of red light irradiation in accelerating wound healing.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-202X
pubmed:author
pubmed:issnType
Print
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
849-57
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:12713592-Antioxidants, pubmed-meshheading:12713592-Apoptosis, pubmed-meshheading:12713592-Cell Division, pubmed-meshheading:12713592-DNA, Complementary, pubmed-meshheading:12713592-DNA Repair, pubmed-meshheading:12713592-Dose-Response Relationship, Radiation, pubmed-meshheading:12713592-Fibroblasts, pubmed-meshheading:12713592-Gene Expression Regulation, pubmed-meshheading:12713592-Humans, pubmed-meshheading:12713592-Ion Channels, pubmed-meshheading:12713592-Mitogen-Activated Protein Kinases, pubmed-meshheading:12713592-Nucleic Acid Hybridization, pubmed-meshheading:12713592-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:12713592-Platelet-Derived Growth Factor, pubmed-meshheading:12713592-Signal Transduction, pubmed-meshheading:12713592-Wound Healing, pubmed-meshheading:12713592-p38 Mitogen-Activated Protein Kinases
pubmed:year
2003
pubmed:articleTitle
cDNA microarray analysis of gene expression profiles in human fibroblast cells irradiated with red light.
pubmed:affiliation
Applied Research Center for Genomic Technology, City University of Hong Kong, Kowloon, Hong Kong, China.
pubmed:publicationType
Journal Article