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pubmed-article:12713420pubmed:abstractTextCallysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C(24) acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC(50) of 15.0 microg/mL.lld:pubmed
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pubmed-article:12713420pubmed:articleTitleCallysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata.lld:pubmed
pubmed-article:12713420pubmed:affiliationGraduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.lld:pubmed
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